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Fibronectin

Fibronectin

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Key features and details

Fibronectin

SKU: 02150025-CF

Synonyms
CIG; Cold insoluble globulin
CAS Number:
86088-83-7
EC Number:
289-149-2
MDL Number:
MFCD00131062
Product Description

Fibronectin

Application Notes

Fibronectin has been shown to stimulate the proliferation of rat osteoblasts in vitro; to induce odontoblast polarization and to regulate the differentiation of human dental pulp cells into odontoblasts. It has wide applications in cellular research into proliferation, differentiation, development and morphology. Precoating of glass, plastic and micro-carrier beads aids cell attachment, particularly those cell which are deficient in cell surface fibronectin. It has been reported that proteolytic digests of fibronectin are mitogenic for CH23 fibroblasts.

Usage Statement

Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.

Key Applications

Glycoproteins

Specifications
SKU 02150025-CF
Alternate Names CIG; Cold insoluble globulin
Application Notes Fibronectin has been shown to stimulate the proliferation of rat osteoblasts in vitro; to induce odontoblast polarization and to regulate the differentiation of human dental pulp cells into odontoblasts. It has wide applications in cellular research into proliferation, differentiation, development and morphology. Precoating of glass, plastic and micro-carrier beads aids cell attachment, particularly those cell which are deficient in cell surface fibronectin. It has been reported that proteolytic digests of fibronectin are mitogenic for CH23 fibroblasts.
Base Catalog Number 150025
Biochemical Physiological Actions Domains of fibronectin bind with collagen, fibrin, heparin, and specific cell membrane receptors. The most notable domain, Arg-Gly-Asp can be recognized by integrins and mediates cell adhesion. Fibronectin is also widely involved in interactions such as the attachment and migration of many cell types, cytoskeletal assembly, tyrosine phosphorylation, and metastasis.
CAS # 86088-83-7
EC Number 289-149-2
Extinction Coefficient E1%= 12.9 (280 nm in 8 M urea-0.2 M NaOH)(Lit.)
Format Lyophilized powder
Isoelectric Point 5.5 - 6.3 (Lit.)
Personal Protective Equipment Eyeshields, Gloves, Respirator filter
Purity ≥90%
Source Bovine Plasma
Sterility Sterile Filtered
Typical Working Concentration Cell culture substratum at 1-5 μg/cm2 or 0.5-50 μg/mL
Usage Statement Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
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