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Hydroxyurea

Hydroxyurea

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Key features and details

Hydroxyurea

SKU: 02102023-CF

Synonyms
Hydroxycarbamide; Carrbamoyl Oxime; N-(Aminocarbonyl) Hydroxyamine; Oxyurea
CAS Number:
127-07-1
Molecular Formula:
CH4N2O2
Beilstein Registry Number:
1741548
EC Number:
204-821-7
MDL Number:
MFCD00007943
Product Description

Hydroxyurea

Application Notes

Hydroxyurea induces apoptosis of in vitro myelogenous leukemia lymphocytes, and the phosphorylation of FADD and p53. It is also used to reduce the rate of painful attacks in sickle-cell disease and has antiretroviral properties in diseases such as AIDS.

Usage Statement

Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.

Key Applications

Cancer Research | Apoptosis and Cell Cycle

Specifications
SKU 02102023-CF
Alternate Names Hydroxycarbamide; Carrbamoyl Oxime; N-(Aminocarbonyl) Hydroxyamine; Oxyurea
Application Notes Hydroxyurea induces apoptosis of in vitro myelogenous leukemia lymphocytes, and the phosphorylation of FADD and p53. It is also used to reduce the rate of painful attacks in sickle-cell disease and has antiretroviral properties in diseases such as AIDS.
Base Catalog Number 102023
Beilstein Registry Number 1741548
Biochemical Physiological Actions Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase.
CAS # 127-07-1
EC Number 204-821-7
Format Crystalline powder
Hazard Statements H361
Molecular Formula CH4N2O2
Personal Protective Equipment Eyeshields, Full-face particle respirator, Gloves, Respirator cartridge, Respirator filter
RTECS Number YT4900000
Safety Symbol GHS08
Usage Statement Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
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