Calmodulin, ≥99%, ≥13,000 U/mg protein, 1 mg

Calmodulin, ≥99%, ≥13,000 U/mg protein, 1 mg

Synonyms Phosphodiesterase 3,5'-cyclic-nucleotide activator; Calcium dependent regulator protein (CDR); Troponin C-Like peptide; CaM; calmodulin

CAS Number: 73298-54-1

EC Number: 277-370-7 MDL Number: MFCD00131869

Packaging size: 1 mg

SKU 0219569101
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Description

Product Description

Calmodulin

Application Notes

Calmodulin is believed to be involved in intracellular Ca2+ homeostasis, cell proliferation, smooth muscle contraction, microtubular function, exocytotic secretion of cellular products, and cell motility. It may be used to activate CaM-dependent phosphodiesterase, calcineurin, CaM Kinases, etc. It is known to potentiate the hormonal stimulation of adenylate cyclase in the brain.

Usage Statement

Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.

Key Applications

Used to activate CaM-dependent phosphodiesterase | involved in intracellular Ca2+ homeostasis; cell proliferation; smooth muscle contraction; microtubular function; exocytotic secretion of cellular products; and cell motility.

Specifications
SKU 0219569101
Alternate Names Phosphodiesterase 3,5'-cyclic-nucleotide activator; Calcium dependent regulator protein (CDR); Troponin C-Like peptide; CaM; calmodulin
Application Notes Calmodulin is believed to be involved in intracellular Ca2+ homeostasis, cell proliferation, smooth muscle contraction, microtubular function, exocytotic secretion of cellular products, and cell motility. It may be used to activate CaM-dependent phosphodiesterase, calcineurin, CaM Kinases, etc. It is known to potentiate the hormonal stimulation of adenylate cyclase in the brain.
Base Catalog Number 19569101
Biochemical Physiological Actions Ca2+ binding protein that is required for activation of cyclic nucleotide-dependent phosphodiesterase. It is also a cofactor/activator of nitric oxide synthase, calcineurin, and many kinases including ATPase, myosin light chain kinase, and CAM kinase I, II, and III. It mediates ryanodine receptor activation by cyclic ADP ribose and is involved in intracellular Ca2+ homeostasis.
CAS # 73298-54-1
EC Number 277-370-7
Extinction Coefficient E1% (278 nm) = 1.8 (0.1 M Imidazole-HCl, 0.001 M EDTA, pH 7.0). If calcium is removed, E1% increases to 2.0.(Lit.)
Format Powder
Formulation Details Lyophilized in 1.7 mM HEPES; pH 7.0; 30 µM CaCl2
Isoelectric Point 3.9-4.3 (Lit.)
Pack Size 1 mg
Personal Protective Equipment Eyeshields, Gloves, respirator filter
Purity ≥99%
Source Bovine brain
Specific Activity ≥13,000 u/mg protein
Unit Definition One unit will activate 3',5'-cyclic-nucleotide phosphodiesterase to 50% Vmax.
Usage Statement Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.