NZ Bovine Fibrinogen, 90% Clottable

NZ Bovine Fibrinogen, 90% Clottable

Synonyms Factor I; Fibrinogen from New Zealand sourced bovine plasma

CAS Number: 9001-32-5 Molecular Weight: α-chain mol wt 63.5 kDa, β-chain mol wt 56 kDa, γ chain mol wt 47 kDa (about 4% carbohydrate content), soluble dimer mol wt 340 kDa (Lit.)

EC Number: 232-598-6 MDL Number: MFCD00163624

SKU 0882022-CF
CN¥6,255.70
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Specifications
SKU 0882022-CF
Alternate Names Factor I; Fibrinogen from New Zealand sourced bovine plasma
Application Notes Bovine fibrinogen has been used in studies of haemostatic therapy in surgical and massive trauma patients. These studies have shown that fibrinogen may prove to be more superior in stopping blood loss when compared to using fresh frozen plasma (FFP). It can be used for preparation of fibrin plates for analysis of fibrinolytic enzymes, a substrate for clotting assays, and study of fibrinogen degradation products.
Base Catalog Number 820221,820224,820225,820226
Biochemical Physiological Actions Fibrinogen is an acute phase protein that is part of the coagulation cascade of proteins. The end result of the cascade is the production of thrombin that converts fibrinogen to fibrin. Thrombin rapidly proteolyzes fibrinogen, releasing fibrinopeptide A. The loss of this small peptide is not sufficient to make the resulting fibrin molecule insoluble, but it tends to form complexes with adjacent fibrin and fibrinogen molecules. Thrombin then cleaves a second peptide, fibrinopeptide B, from fibrin and the fibrin monomers formed then polymerize spontaneously to form an insoluble gel. The polymerized fibrin is held together by noncovalent and electrostatic forces and stabilized by the transamidating enzyme, factor XIIIa, that is produced by the action of thrombin on factor XIII. The insoluble fibrin aggregates (clots) and aggregated platelets then block the damaged blood vessel and prevent further bleeding. The amount of fibrinogen in the plasma can serve as a nonspecific indicator of whether or not an inflammatory process is present in the body. Fibrinogen from any mammalian source will be cleaved by thrombin from any mammalian source.
CAS # 9001-32-5
Concentration Protein: 70% w/w, balance excipients
EC Number 232-598-6
Molecular Weight α-chain mol wt 63.5 kDa, β-chain mol wt 56 kDa, γ chain mol wt 47 kDa (about 4% carbohydrate content), soluble dimer mol wt 340 kDa (Lit.)
Personal Protective Equipment Eyeshields, Gloves, respirator filter
pH 6.4 (1% w/v in saline )
Protein or Enzyme Type Plasma & Blood Proteins
Solubility Soluble in saline. Clear to slightly, hazy solution.
Source New Zealand
Usage Statement Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.