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Bafilomycin A1, 100 μg

Bafilomycin A1, 100 μg

CN¥0.00
Bafilomycin A1

SKU: 0215955580

CAS Number:
88899-55-2
Molecular Weight:
622.84 g/mol
Beilstein Registry Number:
4730700
MDL Number:
MFCD06795130
Packaging size:
100 μg
Product Description

Bafilomycin A1

Application Notes

Bafilomycin A1 is active against gram-positive bacteria and fungi. It is a highly specific inhibitor of vacuolar type H+-ATPase (V-ATPase) in animal cells, plant cells and microorganisms, being effective at nanomolar concentrations in vitro. It inhibits neither F1, F10 nor E1, E2-ATPase. Bafilomycin A1 is useful in distinguishing among different types of ATPases. It is commonly employed to demonstrate the requirement of low endosomal pH for viral uncoating. It can inhibit growth of Capan-1 human pancreatic cancer cells and PC12 cells through apoptosis. Inhibition of V-ATPase by Bafilomycin A1 leads to increase in pH and decreased glycolysis, and thus reduced tumour cell mitosis and proliferation.

Usage Statement

Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.

Key Applications

Active against gram-positive bacteria and fungi | ATPase inhibitor

Specifications
SKU 0215955580
Application Notes Bafilomycin A1 is active against gram-positive bacteria and fungi. It is a highly specific inhibitor of vacuolar type H+-ATPase (V-ATPase) in animal cells, plant cells and microorganisms, being effective at nanomolar concentrations in vitro. It inhibits neither F1, F10 nor E1, E2-ATPase. Bafilomycin A1 is useful in distinguishing among different types of ATPases. It is commonly employed to demonstrate the requirement of low endosomal pH for viral uncoating. It can inhibit growth of Capan-1 human pancreatic cancer cells and PC12 cells through apoptosis. Inhibition of V-ATPase by Bafilomycin A1 leads to increase in pH and decreased glycolysis, and thus reduced tumour cell mitosis and proliferation.
Base Catalog Number 15955580
Beilstein Registry Number 4730700
Biochemical Physiological Actions A specific inhibitor of vacuolar type H+-ATPase (V-ATPase) in animal cells, plant cells and microorganisms.
CAS # 88899-55-2
Format Clear film
Hazard Statements H315-H319-H335
Molecular Weight 622.84 g/mol
Pack Size 100 μg
Personal Protective Equipment Dust mask, Eyeshields, Gloves
Purity ~90%
Safety Symbol GHS07
Source Streptomyces griseus
Usage Statement Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Documents

Certificates of Analysis

Certificates of Analysis
English (United States)
Certificates of Analysis
English (United States)

Datasheets

Datasheets
English (United States)