Ampicillin Trihydrate is commonly used to select for ampicillin resistance in mutated and transformed cells. It is also described for the use of inhancing luminol chemiluminescence.
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|Alternate Names||Aminobenzylpenicillin trihydrate; alpha-Aminobenzylpenicillin trihydrate ;D[-]-α-Aminobenzylpenicillin; 6-[D(-)-α-Aminophenylacetamido]penicillanic acid|
|Application Notes||Ampicillin Trihydrate is commonly used to select for ampicillin resistance in mutated and transformed cells. It is also described for the use of inhancing luminol chemiluminescence.|
|Base Catalog Number||190147|
|Beilstein Registry Number||5399534|
|Biochemical Physiological Actions||A β-lactam antibiotic with an amino group side chain attached to the penicillin structure. Penicillin derivative that inhibits bacterial cell-wall synthesis (peptidoglycan cross-linking) by inactivating transpeptidases on the inner surface of the bacterial cell membrane. Bactericidal only to growing Escherichia coli. Mode of resistance: Cleavage of β-lactam ring of ampicillin by β-lactamase. Antimicrobial spectrum: Gram-negative and Gram-positive bacteria.|
|Melting Point||388 to 392° F (decomposes) (NTP, 1992)|
|Molecular Weight||403.45 g/mol|
|Personal Protective Equipment||Dust mask, Eyeshields, Faceshields, Gloves|
|pKa||At 25 °C ,pKa = 2.5 (-COOH),pKa = 7.3 (-NH2) (Lit.)|
|Safety Symbol||GHS07, GHS08|
|Solubility||1 to 10 mg/mL at 70° F (NTP, 1992)|
|Sterilization of Solutions||Autoclaving solutions of ampicillin will destroy activity. Solutions can be sterilized by filtration (0.22 um filter) and stored frozen (-20 °C or below). Frozen solutions can be stored for up to 3 months.|
|Typical Working Concentration||100 mg/liter for both gram positive and gram negative bacteria. It is typically stable in media at 37 °C for approximately 3 days.|
|Usage Statement||Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.|