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两性霉素B, 来源于链霉菌

Product Description

Amphotericin B

Application Notes

Amphotericin B is used to study the affects of the influx of calcium on antifungal activity and to study the binding and kinetics of Amphotericin B to sterols in monolayers, aqueous solutions, and phospholipid bilayers . It is also commonly used in tissue culture as an antifungal supplement.

Usage Statement

Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.

Key Applications

Antibiotic

Specifications

SKU	02195043-CF
Alternate Names	Amphomoronal; Amphotericine B; Amphozone; Fungilin; Fungisone; Fungizone
Application Notes	Amphotericin B is used to study the affects of the influx of calcium on antifungal activity and to study the binding and kinetics of Amphotericin B to sterols in monolayers, aqueous solutions, and phospholipid bilayers . It is also commonly used in tissue culture as an antifungal supplement.
Base Catalog Number	195043
Beilstein Registry Number	78342
Biochemical Physiological Actions	Amphotericin B is a polyene antifungal antibiotic from Streptomyces. It has an affinity for sterols, primarily ergosterols, of fungal cell membranes. It forms channels in the membranes, causing small molecules to leak out which contributes to cell death. Antimicrobial spectrum: fungi and yeast. Polyene antifungal antibiotic from Streptomyces. Affinity for sterols, primarily ergosterols, of fungal cell membranes. Forms channels in the membranes, causing small molecules to leak out. Antimicrobial spectrum: fungi and yeast
CAS #	1397-89-3
EC Number	215-742-2
Hazard Statements	H315-H319-H335
Melting Point	greater than 338° F (decomposes) (NTP, 1992)
Molecular Formula	C47H73NO17
Molecular Weight	924.091 g/mol
Personal Protective Equipment	dust mask , Eyeshields, Gloves
pKa	5.5 and 10.0.(Lit.)
Potency	>800 µg/mg
RTECS Number	BU2625000
Safety Symbol	GHS07
Solubility	less than 1 mg/mL at 70° F (NTP, 1992)
Source	Streptomyces sp.
Sterilization of Solutions	Sterilization of solutions should be by filtration through teflon membrane filters; Amphotericin B should not be gamma irradiated or autoclaved.
Typical Working Concentration	recommended concentration of 2.5 ug/L (prepared solution use 10 mL/L)
Usage Statement	Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.