Adenosine is a purine nucleoside comprising a molecule of adenine attached to a ribose sugar molecule moiety via a β-N9-glycosidic bond. It plays an important role in energy transfer. It is an endogenous purine nucleoside that modulates physiological process wherein cellular signaling by adenosine occurs through four known adenosine receptor subtypes (A1, A2A, A2B, and A3) Adenosine is an anti-inflammatory agent at the A(2A) receptor. Cardioprotective effects may relate to activation of A1 adenosine receptors.
Adenosine is used in topical treatment of foot wounds in diabetes mellitus and also used for the treatment or prevention of cardiac arrhythmias (irregular heartbeat).It is used to cause dilation of the blood vessels.
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|Alternate Names||9--D-Ribofuranosyladenine; Adenine riboside; Adenine-9--D-ribofuranoside;Adenocor;9-beta-D-Ribofuranosyl-9H-purin-6-amine;(3R,4R,5R)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol|
|Application Notes||Adenosine is used in topical treatment of foot wounds in diabetes mellitus and also used for the treatment or prevention of cardiac arrhythmias (irregular heartbeat).It is used to cause dilation of the blood vessels.|
|Base Catalog Number||199803|
|Beilstein Registry Number||93029|
|Biochemical Physiological Actions||Endogenous neurotransmitter at adenosine receptors. Cardioprotective effects may relate to activation of A1 adenosine receptors. The antiplatelet and anti−inflammatory actions of adenosine appear to be mediated via the A2 adenosine receptor. In contrast, adenosine appears to be a pro-inflammatory mediator in asthma and chronic obstructive pulmonary disease (COPD).|
|Melting Point||233 - 238 °C|
|Optical Rotation||-68.0° to -72.0° (c=2, NaOH 1:20)|
|Personal Protective Equipment||Eyeshields, Gloves, respirator filter|