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3-异丁基-1-甲基黄嘌呤(IBMX)

3-异丁基-1-甲基黄嘌呤(IBMX)

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CAS:28822-58-4 3-异丁基-1-甲基-2,6(1H,3H)-嘌呤二酮 IBMX是一种有效的非特异性腺苷3',5'-环磷酸二酯酶(cAMP-PDE)4抑制剂,效果优于茶碱,还可抑制cGMP磷酸二酯酶。IBMX抑制环核苷酸PDE,随后抑制环核苷酸水解,导致环腺苷酸和鸟苷3',5'-环磷酸的聚合。

SKU: 02195262-CF

Synonyms
IBMX; MIX; MeiBu-Xan; IBX; 1-Methyl-3-isobutylxanthine, 3,7-Dihydro-1-methyl-3-(2-methylpropyl)-1H-purine-2,6-dione, 3-Isobutyl-1-methyl-2,6(1H,3H)-purinedione
CAS Number:
28822-58-4
Molecular Formula:
C10H14N4O2
Molecular Weight:
222.25
Beilstein Registry Number:
247859
EC Number:
249-259-3
MDL Number:
MFCD00005584
Product Description

IBMX has been shown to be a potent, non-specific inhibitor of adenosine 3',5'-cyclic monophosphate phosphodiesterase (cAMP PDE)4, significantly more effective than theophylline. Also inhibits cGMP phosphodiesterases. IBMX inhibits cyclic nucleotide PDE with subsequent inhibition of cyclic nucleotide hydrolysis, resulting in accumulation of cyclic AMP and guanosine 3',5'-cyclic monophosphate.

Application Notes

IBMX helps in inhibition of phenylephrine-induced release of 5-hydroxytryptamine from neuroendocrine epithelial cells of the airway mucosa (IC50 = 1.3 uM). Also inhibits ion channels in the neuromuscular junction, GH3 cells, and vascular smooth muscle cells. Inhibits the growth of carcinoma cells both in vivo and in vitro in mice.

Usage Statement

Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.

Key Applications

Inhibition | Cell Signalling

Specifications
SKU 02195262-CF
Alternate Names IBMX; MIX; MeiBu-Xan; IBX; 1-Methyl-3-isobutylxanthine, 3,7-Dihydro-1-methyl-3-(2-methylpropyl)-1H-purine-2,6-dione, 3-Isobutyl-1-methyl-2,6(1H,3H)-purinedione
Application Notes IBMX helps in inhibition of phenylephrine-induced release of 5-hydroxytryptamine from neuroendocrine epithelial cells of the airway mucosa (IC50 = 1.3 uM). Also inhibits ion channels in the neuromuscular junction, GH3 cells, and vascular smooth muscle cells. Inhibits the growth of carcinoma cells both in vivo and in vitro in mice.
Base Catalog Number 195262
Beilstein Registry Number 247859
Biochemical Physiological Actions Non-specific inhibitor of cAMP and cGMP phosphodiesterases. The increase in cAMP level as a result of phosphodiesterase inhibition by IBMX activates PKA leading to decreased proliferation, increased differentiation, and induction of apoptosis. IBMX inhibits phenylephrine-induced release of 5-hydroxytryptamine from neuroendocrine epithelial cells of the airway mucosa (IC50: 1.3 µM). Also serves as an adenosine receptor antagonist. Shown to inhibit ion channels in the neuromuscular junction, GH3 cells, and vascular smooth muscle cells. Induces calcium release from intracellular stores in sensory neurons.
CAS # 28822-58-4
EC Number 249-259-3
Melting Point 195 - 202 °C
Molecular Formula C10H14N4O2
Molecular Weight 222.25
Personal Protective Equipment Dust mask , Eyeshields, Faceshields, Gloves
RTECS Number ZD8500000
Safety Symbol GHS07
Solubility Soluble in Krebs-Henseleit bicarbonate buffer, ethanol (10 mg/mL or 25 mg/mL with sonication), DMSO (1 M with warming), or aqueous NaOH (pH 9.5); slightly soluble in water (0.3 mg/mL hot water). Solubility in 45% (w/v) aqueous 2-hydroxy-propyl-b-cyclodextrin is 3.2 mg/mL.
Usage Statement Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
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