Patulin is a mycotoxin produced by a variety of molds, such as, Aspergillus and Penicillium. It blocks the farnesylation of proteins in a cell free assay. It inhibits the incorporation of 3H-mevalonate into proteins found in complete cells.
Application Notes
Patulin is used as an inhibitor of potassium uptake and as an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase and to induce intra- and intermolecular protein crosslinking. It is used to study patulin contamination of bottled wine, DNA-damaging activity of patulin in Escherichia coli., and molecular cloning and functional characterization of two CYP619 cytochrome P450s involved in patulin biosynthesis.
Usage Statement
Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Key Applications
Antibiotic | Inhibitor of potassium uptake | Study of patulin contamination of bottled wine
| SKU | 0215998902 |
| Alternate Names | 4-Hydroxy-4H-furo[3,2-c]pyran-2(6H)-one; claviformin; clavitin; expansin; clavacin; penicidin; mycoin C; mycoin; leucopin; tercinin |
| Application Notes | Patulin is used as an inhibitor of potassium uptake and as an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase and to induce intra- and intermolecular protein crosslinking. It is used to study patulin contamination of bottled wine, DNA-damaging activity of patulin in Escherichia coli., and molecular cloning and functional characterization of two CYP619 cytochrome P450s involved in patulin biosynthesis. |
| Base Catalog Number | 15998902 |
| Beilstein Registry Number | 149675 |
| Biochemical Physiological Actions | Patulin is genotoxic and may be carcinogenic. It is an inhibitor of potassium uptake and an inducer of ion flux across cell membranes, potentially involving Na<sup>+</sup>-K<sup>+</sup> dependent ATPase. It induces intra- and intermolecular protein crosslinking. CYP619 cytochrome P450s are involved in biosynthesis of patulin in <i>Aspergillus clavatus</i>. |
| CAS # | 149-29-1 |
| EC Number | 205-735-2 |
| Extinction Coefficient | EM(276 nm) = 14,600 (methanol)(Lit.) |
| Hazard Statements | H300-H315 |
| Melting Point | 107 - 110 °C(Lit.) |
| Molecular Formula | C7H6O4 |
| Molecular Weight | 154.1 |
| Pack Size | 2 mg |
| Personal Protective Equipment | Eyeshields, Gloves |
| RTECS Number | LV2625000 |
| Safety Symbol | GHS06 |
| Solubility | Soluble in ethyl acetate (5 mg in 0.1 mL), in dichloromethane (10 mg/mL), in water, DMSO(10 mg/mL) and ethanol (25 mg/ mL). Sparingly soluble in ethyl ether or benzene. |
| Usage Statement | Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department. |
![MP COA [159989] lot ID: 7719K](https://www.mpbio.com/static/version1781680552/frontend/Mpbio/luma/en_US/images/document.png "MP COA [159989] lot ID: 7719K")
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