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    Niclosamide

    As low as CA$166.58
    In stock
    Only %1 left

    SKU:  02155827-CF

    Key features and details

    Niclosamide
    Synonyms
    2´,5-Dichloro-4-nitrosalicylanilide
    CAS Number:
    50-65-7
    Molecular Formula:
    C13H8Cl2N2O4
    Molecular Weight:
    327.117 g/mol
    Beilstein Registry Number:
    2820605
    EC Number:
    200-056-8
    MDL Number:
    MFCD00057597
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    Product Description

    Niclosamide

    Application Notes

    Niclosamide is effective against cestodes that infect humans. Niclosamide is used to study the Wnt/Frizzled-1 signaling pathway. It is used to inhibit the transcription and DNA binding of NF-κB in AML cells and ito induce apoptosis.

    Usage Statement

    Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.

    Key Applications

    Antibiotic | Inhibit the transcription and DNA binding of NF-κB in AML cells

    Specifications
    SKU 02155827-CF
    Alternate Names 2´,5-Dichloro-4-nitrosalicylanilide
    Application Notes Niclosamide is effective against cestodes that infect humans. Niclosamide is used to study the Wnt/Frizzled-1 signaling pathway. It is used to inhibit the transcription and DNA binding of NF-κB in AML cells and ito induce apoptosis.
    Base Catalog Number 155827
    Beilstein Registry Number 2820605
    Biochemical Physiological Actions Niclosamide uncouples oxidative phosphorylation in the tapeworm. It inhibits mitochondrial oxidative phosphorylation of parasitic helminths. It inhibits the NF-κB pathway in acute myelogenous leukemia (AML) cells. Niclosamide inhibits the transcription and DNA binding of NF-κB. It blocks tumor necrosis factor-induced IκBα phosphorylation, translocation of p65, and expression of NF-κB– regulated genes in AML cells. It increases ROS levels to induce apoptosis in AML cells.
    CAS # 50-65-7
    EC Number 200-056-8
    Format Powder
    Hazard Statements H400
    Melting Point 230 °C
    Molecular Formula C13H8Cl2N2O4
    Molecular Weight 327.117 g/mol
    Personal Protective Equipment Eyeshields, Gloves, Respirator filter
    Purity ≥98%
    RTECS Number VN8400000
    Safety Symbol GHS09
    Solubility Water Solubility1.6 mg/L (at 20 °C)
    Usage Statement Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
    Vapor Pressure <9.87X10-9 mm Hg at 20 deg C
    Documents

    Certificate of Analysis (COA)

    MP COA [155827] lot ID: M2059A MP COA [155827] lot ID: M2059A
    MP COA [155827] lot ID: S0502 MP COA [155827] lot ID: S0502
    MP COA [155827] lot ID: Q5765 MP COA [155827] lot ID: Q5765

    Safety Data Sheets

    English (United States)
    MP SDS [155827] MP SDS [155827]