Recombinant Human IGF-I

Recombinant Human IGF-I

Synonyms Insulin-like Growth Factor-I, Somatamedin C, IGF-IA; GPETLCGAEL VDALQFVCGD RGFYFNKPTG YGSSSRRAPQ TGIVDECCFR SCDLRRLEMY CAPLKPAKSA

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SKU 08P98508-CF
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$104.20
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Description

Product Description

The IGFs are mitogenic polypeptide growth factors that stimulate the proliferation and survival of various cell types including muscle, bone, and cartilage tissue in vitro. IGFs are predominantly produced by the liver, although a variety of tissues produce the IGFs at distinctive times. The IGFs belong to the Insulin gene family, which also contains insulin and relaxin. The IGFs are similar by structure and function to insulin, but have a much higher growth-promoting activity than insulin. IGF-II expression is influenced by placenta lactogen, while IGF-I expression is regulated by growth hormone. Both IGF-I and IGF-II signal through the tyrosine kinase type I receptor (IGF-IR), but, IGF-II can also signal through the IGF-II/Mannose-6-phosphate receptor. Mature IGFs are generated by proteolytic processing of inactive precursor proteins, which contain N-terminal and C-terminal propeptide regions. Recombinant human IGF-I and IGF-II are globular proteins containing 70 and 67 amino acids, respectively, and 3 intra-molecular disulfide bonds.

Application Notes

Used in studies of Angiogenesis/Cardiovascular; Bone, Skeletal, Cartilage; Diabetes / Weight Regulation; Inflammation ; Proliferation; Wound Healing

Key Applications

Mammalian Cell Culture | Growth Factor supplement

Specifications
SKU 08P98508-CF
Alternate Names Insulin-like Growth Factor-I, Somatamedin C, IGF-IA; GPETLCGAEL VDALQFVCGD RGFYFNKPTG YGSSSRRAPQ TGIVDECCFR SCDLRRLEMY CAPLKPAKSA
Application Notes Used in studies of Angiogenesis/Cardiovascular; Bone, Skeletal, Cartilage; Diabetes / Weight Regulation; Inflammation ; Proliferation; Wound Healing
Applications Mammalian Cell Culture | Growth Factor supplement
Product Families Description The IGFs are mitogenic polypeptide growth factors that stimulate the proliferation and survival of various cell types including muscle, bone, and cartilage tissue in vitro. IGFs are predominantly produced by the liver, although a variety of tissues produce the IGFs at distinctive times. The IGFs belong to the Insulin gene family, which also contains insulin and relaxin. The IGFs are similar by structure and function to insulin, but have a much higher growth-promoting activity than insulin. IGF-II expression is influenced by placenta lactogen, while IGF-I expression is regulated by growth hormone. Both IGF-I and IGF-II signal through the tyrosine kinase type I receptor (IGF-IR), but, IGF-II can also signal through the IGF-II/Mannose-6-phosphate receptor. Mature IGFs are generated by proteolytic processing of inactive precursor proteins, which contain N-terminal and C-terminal propeptide regions. Recombinant human IGF-I and IGF-II are globular proteins containing 70 and 67 amino acids, respectively, and 3 intra-molecular disulfide bonds.
Protein or Enzyme Type Cytokines
Purity 0.98
Research Areas Angiogenesis/Cardiovascular; Bone, Skeletal, Cartilage; Diabetes / Weight Regulation; Inflammation ; Proliferation; Wound Healing
Source E. Coli
Species Reactivity Bacteria; Chicken; Cow; Frog; Horse; Monkey; Mouse; Pig; Rat; Sheep; Tiger Salamander
Specific Activity The <strong>ED</strong><sub>50</sub> was determined by a cell proliferation assay using FDC-P1 cells is ≤ 2.0 ng/mL, corresponding to a specific activity of ≥ 5 x 10<sup>5</sup> units/mg.
Storage and Handling Store at-20 °C.