β-2-Microglobulin is a cancer and renal biomarker. Excellent for controls or calibrators in enzyme assays. Beta 2-microglobulin is present in small amounts in serum, csf, and urine of normal people, and to a much greater degree in the urine and plasma of patients with tubular proteinaemia, renal failure, or kidney transplants. Human Beta 2 microglobulin levels can rise either because its rate of synthesis has increased (e.g. in AIDS, malignant monoclonal plasma cell dyscrasia, solid tumors and autoimmune disease) or because of impaired renal filtration (e.g. due to renal insufficiency, graft rejection or nephrotoxicity induced by post-transplantation immunosuppressive therapy). Beta-2 microglobulin levels might also be elevated in multiple myeloma and lymphoma cases. Dialysis-related amyloidosis develops after a long-term hemodialysis, it can aggregate into amyloid fibers that deposit in joint spaces.
beta-2-Microglobulin is a cancer and renal biomarker. Excellent for controls or calibrators in enzyme assays.
Immunoassays | Calibrators in enzyme assays
|Application Notes||beta-2-Microglobulin is a cancer and renal biomarker. Excellent for controls or calibrators in enzyme assays.|
|Applications||Immunoassays | Calibrators in enzyme assays|
|Physical Appearance||Lyophilized powder|
|Preparation Method||Lyophilized from 0.02M Ammonium Bicarbonate (may contain traces of buffer salt).|
|Purity||>98% by SDS PAGE and Cellulose Acetate Electrophoresis.|
|Research Areas||Blood Proteins||Cancer Biomarkers|
|Specificity||Immunological identity verified by radial immunodiffusion. Cellulose acetate electrophoresis shows one band indicating β2 electrophoretic mobility. SDS-PAGE shows one band corresponding to a molecular weight of approximately 12;000.|
|Storage and Handling||Store at 2-8°C. For long-term storage after reconstitution; aliquot and store at -20 ° C.|