beta-2-Microglobulin

beta-2-Microglobulin

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SKU 0877095-CF
Price:
$62.95
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Description

Product Description

β-2-Microglobulin is a cancer and renal biomarker. Excellent for controls or calibrators in enzyme assays. Beta 2-microglobulin is present in small amounts in serum, csf, and urine of normal people, and to a much greater degree in the urine and plasma of patients with tubular proteinaemia, renal failure, or kidney transplants. Human Beta 2 microglobulin levels can rise either because its rate of synthesis has increased (e.g. in AIDS, malignant monoclonal plasma cell dyscrasia, solid tumors and autoimmune disease) or because of impaired renal filtration (e.g. due to renal insufficiency, graft rejection or nephrotoxicity induced by post-transplantation immunosuppressive therapy). Beta-2 microglobulin levels might also be elevated in multiple myeloma and lymphoma cases. Dialysis-related amyloidosis develops after a long-term hemodialysis, it can aggregate into amyloid fibers that deposit in joint spaces.

Application Notes

beta-2-Microglobulin is a cancer and renal biomarker. Excellent for controls or calibrators in enzyme assays.

Key Applications

Immunoassays | Calibrators in enzyme assays

Specifications
SKU 0877095-CF
Application Notes beta-2-Microglobulin is a cancer and renal biomarker. Excellent for controls or calibrators in enzyme assays.
Formulation Lyophilized
Grade Iodination Grade
Applications Immunoassays | Calibrators in enzyme assays
Physical Appearance Lyophilized powder
Preparation Method Lyophilized from 0.02M Ammonium Bicarbonate (may contain traces of buffer salt).
Presentation Lyophilized powder
Purity >98% by SDS PAGE and Cellulose Acetate Electrophoresis.
Research Areas Blood Proteins||Cancer Biomarkers
Source Human urine
Specificity Immunological identity verified by radial immunodiffusion. Cellulose acetate electrophoresis shows one band indicating β2 electrophoretic mobility. SDS-PAGE shows one band corresponding to a molecular weight of approximately 12;000.
Storage and Handling Store at 2-8°C. For long-term storage after reconstitution; aliquot and store at -20 ° C.
Trade Name ImmunO™