Apigenin

Apigenin

Synonyms 4',5,7-Trihydroxyflavone; Chamomile; Apigenine; Apigenol; C.I. Natural Yellow 1; 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one; 2-(p-Hydroxyphenyl)-5,7-dihydroxychromone; Pelargidenon 1449; 4',5,7-Trihydroxyflavone; Versulin

CAS Number: 520-36-5 Molecular Formula: C15H10O5 Molecular Weight: 270.24 g/mol

Beilstein Registry Number: 262620 EC Number: 208-292-3 MDL Number: MFCD00006831

Packaging size: 100 mg

SKU 0520367180
Price:
$267.25
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Description

Product Description

Apigenin

Application Notes

Apigenin is an inhibitor of cell proliferation by arresting cells in the G2/M phase. It has also been reported to inhibit topoisomerase I catalyzed DNA religation and enhance gap junctional intercellular communication. May induce morphological differentiation (elongation and arborization) of neurites. It also inhibits protein kinase C by competing with ATP (IC50 = 10 ± 0.5 uM), tyrosine kinases fibroblast growth factor receptor (IC50 = 20 uM), pp60v-src (IC50 > 200 uM); inhibits estrogen synthetase.

Usage Statement

Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Key Applications

Inhibitor of cell proliferation||Induces morphological differentiation

Specifications
SKU 0520367180
Alternate Names 4',5,7-Trihydroxyflavone; Chamomile; Apigenine; Apigenol; C.I. Natural Yellow 1; 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one; 2-(p-Hydroxyphenyl)-5,7-dihydroxychromone; Pelargidenon 1449; 4',5,7-Trihydroxyflavone; Versulin
Application Notes Apigenin is an inhibitor of cell proliferation by arresting cells in the G2/M phase. It has also been reported to inhibit topoisomerase I catalyzed DNA religation and enhance gap junctional intercellular communication. May induce morphological differentiation (elongation and arborization) of neurites. It also inhibits protein kinase C by competing with ATP (IC50 = 10 ± 0.5 uM), tyrosine kinases fibroblast growth factor receptor (IC50 = 20 uM), pp60v-src (IC50 > 200 uM); inhibits estrogen synthetase.
Beilstein Registry Number 262620
Biochemical Physiological Actions A plant flavonoid that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. Inhibition of growth through cell cycle arrest and induction of apoptosis appear to be related to induction of p53.Inhibits PMA-mediated tumor promotion by inhibiting protein kinase C1 and the resulting suppression of oncogene expression. It has also been reported to inhibit topoisomerase I-catalyzed DNA re-ligation and enhance gap junctional intercellular communication.
EC Number 208-292-3
Format powder
Hazard Statements H315-H319-H335
Applications Inhibitor of cell proliferation||Induces morphological differentiation
MDL # MFCD00006831
Melting Point 345-350 deg C
Molecular Formula C15H10O5
Molecular Weight 270.24 g/mol
Pack Size 100 mg
Personal Protective Equipment Dust mask, Eyeshields, Gloves
Physical Appearance Yellow Powder
Product Families Description Apigenin
Product Overview Apigenin
RTECS Number LK9276000
Safety Symbol GHS07
Solubility Soluble in <a class="pubchem-internal-link CID-702" href="https://pubchem.ncbi.nlm.nih.gov/compound/ethanol">ethanol</a>, <a class="pubchem-internal-link CID-1049" href="https://pubchem.ncbi.nlm.nih.gov/compound/pyridine">pyridine</a>, concentrated <a class="pubchem-internal-link CID-1118" href="https://pubchem.ncbi.nlm.nih.gov/compound/sulfuric%20acid">sulfuric acid</a>; very soluble in dilute alkalies
Storage and Handling Store at -0 °C.
Usage Statement Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Vapor Pressure 1.01X10-10 mm Hg at 25 deg C (est)