Guanidine Thiocyanate
Description
Product Description
Guanidine Thiocyanate
Application Notes
Guanidine Thiocyanate is often used in the isolation of intact ribonucleic acid to eliminate RNase activity. A 4 M solution of guanidine thiocyanate irreversibly inactivates RNase. In the presence of guanidine thiocyanate, proteins dissolve readily, cellular structures disintegrate and nucleoproteins dissociate from nucleic acids, as protein secondary structure is lost.
Usage Statement
Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.
Key Applications
Strong denaturant
Specifications
| SKU | 04820991-CF |
| Alternate Names | Guanidinium rhodanide; Guanidinium thiocyanate |
| Application Notes | Guanidine Thiocyanate is often used in the isolation of intact ribonucleic acid to eliminate RNase activity. A 4 M solution of guanidine thiocyanate irreversibly inactivates RNase. In the presence of guanidine thiocyanate, proteins dissolve readily, cellular structures disintegrate and nucleoproteins dissociate from nucleic acids, as protein secondary structure is lost. |
| Beilstein Registry Number | 3563461 |
| EC Number | 209-812-1 |
| Format | Crystalline Granules |
| Grade | Research Grade |
| Hazard Statements | H302 + H312 + H332-H314-H412, Contact with acids liberates very toxic gas. |
| Applications | Strong denaturant |
| Loss on Drying | <1% |
| MDL # | MFCD00013027 |
| Molecular Formula | CH5N3 • HSCN |
| Molecular Weight | 118.158 g/mol |
| Personal Protective Equipment | Dust mask, Eyeshields, Gloves |
| Physical Appearance | Hard; White Crystalline Granules |
| Product Families Description | Guanidine Thiocyanate |
| Product Overview | Guanidine Thiocyanate |
| Purity | >98% |
| Safety Symbol | GHS05, GHS07 |
| Sterilization of Solutions | Solutions can be sterilized by filtration using a 0.2 µm filter. |
| Storage and Handling | Store at Room Temperature (15-30°C). Protect from light. |
| Usage Statement | Research Use Only (RUO). Ready for CE IVD labeling of clinical applications. |
| UV Visible Absorbance | OD280 (6 M aq soln): <0.5 |