Guanidine Thiocyanate

Guanidine Thiocyanate

Synonyms Guanidinium rhodanide; Guanidinium thiocyanate

CAS Number: 593-84-0 Molecular Formula: CH5N3 • HSCN Molecular Weight: 118.158 g/mol

Beilstein Registry Number: 3563461 EC Number: 209-812-1 MDL Number: MFCD00013027

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SKU 04820991-CF
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Description

Product Description

Guanidine Thiocyanate

Application Notes

Guanidine Thiocyanate is often used in the isolation of intact ribonucleic acid to eliminate RNase activity. A 4 M solution of guanidine thiocyanate irreversibly inactivates RNase. In the presence of guanidine thiocyanate, proteins dissolve readily, cellular structures disintegrate and nucleoproteins dissociate from nucleic acids, as protein secondary structure is lost.

Usage Statement

Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.

Key Applications

Strong denaturant

Specifications
SKU 04820991-CF
Alternate Names Guanidinium rhodanide; Guanidinium thiocyanate
Application Notes Guanidine Thiocyanate is often used in the isolation of intact ribonucleic acid to eliminate RNase activity. A 4 M solution of guanidine thiocyanate irreversibly inactivates RNase. In the presence of guanidine thiocyanate, proteins dissolve readily, cellular structures disintegrate and nucleoproteins dissociate from nucleic acids, as protein secondary structure is lost.
Beilstein Registry Number 3563461
EC Number 209-812-1
Format Crystalline Granules
Grade Research Grade
Hazard Statements H302 + H312 + H332-H314-H412, Contact with acids liberates very toxic gas.
Applications Strong denaturant
Loss on Drying <1%
MDL # MFCD00013027
Molecular Formula CH5N3 • HSCN
Molecular Weight 118.158 g/mol
Personal Protective Equipment Dust mask, Eyeshields, Gloves
Physical Appearance Hard; White Crystalline Granules
Product Families Description Guanidine Thiocyanate
Product Overview Guanidine Thiocyanate
Purity >98%
Safety Symbol GHS05, GHS07
Sterilization of Solutions Solutions can be sterilized by filtration using a 0.2 µm filter.
Storage and Handling Store at Room Temperature (15-30°C). Protect from light.
Usage Statement Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.
UV Visible Absorbance OD280 (6 M aq soln): <0.5