Dino

Q-VD-OPh

Q-VD-OPh

Synonyms Q-Val-Asp-OPH; Q-VD-OPH; Quinoline-Val-Asp-CH2-O-Ph

CAS Number: 1135695-98-5 Molecular Formula: C26H25F2N3O6 Molecular Weight: 513.498 g/mol

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SKU 03OPH109-CF
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$235.30
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Description

Product Description

Q-Vd-Oph

Application Notes

Q-VD-OPh is a cell-permeable, irreversible inhibitor of caspase activity (Philipp J. Jost,2009). The "OPH" trap provides these important features Nontoxic (preliminary study showed no evidence of toxicity in mice injected intraperitoneally with more than 1000 mg/kg) and Potency (Our new caspase inhibitors show significant improvement in potency. IC50 values against purified caspases are now in the nanomolar range. In an in vitro cell based assay, greater than 90% inhibition of apoptosis was achieved). Note: Optimal dilutions should be determined by the laboratory for each specific applications.

Usage Statement

Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Key Applications

Inhibitor||Caspase Inhibitor / Apoptosis Inhibitor

Specifications
SKU 03OPH109-CF
Application Notes Q-VD-OPh is a cell-permeable, irreversible inhibitor of caspase activity (Philipp J. Jost,2009). The "OPH" trap provides these important features Nontoxic (preliminary study showed no evidence of toxicity in mice injected intraperitoneally with more than 1000 mg/kg) and Potency (Our new caspase inhibitors show significant improvement in potency. IC50 values against purified caspases are now in the nanomolar range. In an in vitro cell based assay, greater than 90% inhibition of apoptosis was achieved). Note: Optimal dilutions should be determined by the laboratory for each specific applications.
Format Off white semi solid
Applications Inhibitor||Caspase Inhibitor / Apoptosis Inhibitor
Molecular Formula C26H25F2N3O6
Molecular Weight 513.498 g/mol
Physical Appearance Off-white semi solid
Product Families Description Q-VD-OPH
Product Overview Q-Vd-Oph
Purity HPLC > 95%
Storage and Handling Keep Cool and Dry. Store reagent desiccated at 2 - 8 ° C upon arrival. Lyophilized; samples are stable at least for 1 year; desiccated; at 2 - 8 ° C. Upon reconstitution in 100% DMSO; stock concentrations of 10 - 20 mM are stable for 6 months at ≤ -20 °C. Avoid repeated freeze/thaw cycles by aliquoting the stock solution prior to freezing.
Usage Statement Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.