(-)-Epigallocatechin Gallate

(-)-Epigallocatechin Gallate

Synonyms (2R,3R)-2-(3,4,5-Trihydroxyphenyl)- 3,4-dihydro- 1(2H)- benzopyran-3,5,7- triol 3-(3,4,5-trihydroxybenzoate); (-)-Epigallocatechin 3-O-gallate; EGCG; (−)-cis-3,3′,4′,5,5′,7-Hexahydroxy-flavane-3-gallate; (−)-cis-2-(3,4,5-Trihydroxyphenyl)-3,4-dihydro-1(2H)-benzopyran-3,5,7-triol 3-gallate

CAS Number: 989-51-5 Molecular Formula: C22H18O11 Molecular Weight: 458.375 g/mol

MDL Number: MFCD00075940

Configure Your Product:

SKU 02199165-CF
Price:
$39.25
In Stock
Request a quote
Description

Product Description

(-)-Epigallocatechin Gallate

Application Notes

(-)-Epigallocatechin Gallate inhibits cellular oxidation of low density lipoproteins. It also inhibits the peroxynitrite-induced formation of the oxidative injury markers 8-hydroxy-2-deoxy guanosine and 3-nitrotyrosine, apoptosis in human prostate cancer cells. Selectively inhibits activation of JNK/SAPK signaling pathway and suppresses proliferation of vascular smooth muscle cells. Shows growth inhibitory effects on tumor cells but not their normal counterparts. Inhibits telomerase. A fast-binding and reversible fatty acid synthase inhibitor. Inhibits PMA-induced skin thickening. Inhibits activation of interleukin-1α mRNA and protein expression. Inhibits nitric oxide synthase (iNOS) gene expression. At µM concentrations, it inhibits VEGF-induced tyrosine phosphorylation.

Usage Statement

Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.

Key Applications

Inhibits cellular oxidation

Specifications
SKU 02199165-CF
Alternate Names (2R,3R)-2-(3,4,5-Trihydroxyphenyl)- 3,4-dihydro- 1(2H)- benzopyran-3,5,7- triol 3-(3,4,5-trihydroxybenzoate); (-)-Epigallocatechin 3-O-gallate; EGCG; (−)-cis-3,3′,4′,5,5′,7-Hexahydroxy-flavane-3-gallate; (−)-cis-2-(3,4,5-Trihydroxyphenyl)-3,4-dihydro-1(2H)-benzopyran-3,5,7-triol 3-gallate
Application Notes (-)-Epigallocatechin Gallate inhibits cellular oxidation of low density lipoproteins. It also inhibits the peroxynitrite-induced formation of the oxidative injury markers 8-hydroxy-2-deoxy guanosine and 3-nitrotyrosine, apoptosis in human prostate cancer cells. Selectively inhibits activation of JNK/SAPK signaling pathway and suppresses proliferation of vascular smooth muscle cells. Shows growth inhibitory effects on tumor cells but not their normal counterparts. Inhibits telomerase. A fast-binding and reversible fatty acid synthase inhibitor. Inhibits PMA-induced skin thickening. Inhibits activation of interleukin-1α mRNA and protein expression. Inhibits nitric oxide synthase (iNOS) gene expression. At µM concentrations, it inhibits VEGF-induced tyrosine phosphorylation.
Biochemical Physiological Actions Antioxidant polyphenol flavonoid that inhibits telomerase and DNA methyltransferase. EGCG blocks the activation of EGF receptors and HER-2 receptors. ECGG inhibits fatty acid synthase and glutamate dehydrogenase activity.
Extinction Coefficient EM(275 nm) = 11,500 (ethanol)(Lit.)
Format powder
Applications Inhibits cellular oxidation
MDL # MFCD00075940
Melting Point 140 - 142 °C
Molecular Formula C22H18O11
Molecular Weight 458.375 g/mol
Optical Rotation -185° ±2° (ethanol)(Lit.)
Personal Protective Equipment Eyeshields, Gloves, Respirator filter
Physical Appearance Light Pink Powder
Product Families Description (-)-Epigallocatechin gallate
Product Overview (-)-Epigallocatechin Gallate
Purity ≥95%
RTECS Number KB5200000
Source Green tea; Folium Camelliae
Storage and Handling Store at +4 °C.
Usage Statement Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.