Hemin Chloride

Hemin Chloride

Synonyms Hemin Chloride; Chloroferriprotoporphyrin; Chlorohemin; Chloro(protoprophyrinato) iron (III); Ferriprotoporphyrin IX chloride; Hematin hydrochloride; Protohemin IX; (SP-5-13)-Chloro [7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)- N21, N22, N23, N24] ferrate(2-) dihydrogen; Chloro [dihydrogen 3,7,12,17-tetramethyl-8,13-divinyl-2, 18-porphinedipropionato (2-)]iron; 1,3,5,8-tetramethyl-2,4-divinylporphine-6,7- dipropionic acid ferrichloride; Teichmann's crystals; Ferriheme chloride

CAS Number: 16009-13-5 Molecular Formula: C34H32ClFeN4O4

Beilstein Registry Number: 5229914 EC Number: 240-140-1 MDL Number: MFCD00010726

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SKU 02198820-CF
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Description

Product Description

Hemin Chloride

Application Notes

Hemin is used in the management of porphyria attacks, particularly in acute intermittent porphyria.It may be used to study the expression and repression of heme oxygenase 1 (HO-1) as well as the activity of HO-1.Hemin is used for the following applications:• To study bacterial strains and growth conditions• Used in short-term colony assays (the culture medium consists of hemin along with other components)• Cell transfections• It may be used in ß-hematin formation assay for analyzing the inhibitory activity of MMV (Medicines for Malaria Venture) Malaria Box compounds against the formation of β-hematin.

Usage Statement

Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.

Specifications
SKU 02198820-CF
Alternate Names Hemin Chloride; Chloroferriprotoporphyrin; Chlorohemin; Chloro(protoprophyrinato) iron (III); Ferriprotoporphyrin IX chloride; Hematin hydrochloride; Protohemin IX; (SP-5-13)-Chloro [7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)- N21, N22, N23, N24] ferrate(2-) dihydrogen; Chloro [dihydrogen 3,7,12,17-tetramethyl-8,13-divinyl-2, 18-porphinedipropionato (2-)]iron; 1,3,5,8-tetramethyl-2,4-divinylporphine-6,7- dipropionic acid ferrichloride; Teichmann's crystals; Ferriheme chloride
Application Notes Hemin is used in the management of porphyria attacks, particularly in acute intermittent porphyria.It may be used to study the expression and repression of heme oxygenase 1 (HO-1) as well as the activity of HO-1.Hemin is used for the following applications:• To study bacterial strains and growth conditions• Used in short-term colony assays (the culture medium consists of hemin along with other components)• Cell transfections• It may be used in ß-hematin formation assay for analyzing the inhibitory activity of MMV (Medicines for Malaria Venture) Malaria Box compounds against the formation of β-hematin.
Beilstein Registry Number 5229914
Biochemical Physiological Actions Hemin, the oxidized version of heme, is an iron-containing prosthetic group for a diverse group of proteins. Free heme, which can be released from hemoglobin following hemolysis, is pro-inflammatory and contributes to iron-derived reactive oxygen species. Free hemin levels may be upregulated in various pathological conditions and can contribute to various inflammatory conditions including vascular disorders, renal failure, and immune-mediated disorders. Hemin may be used to study the expression and represson of heme oxygenase 1 (HO-1) as well as the activity of HO-1. Hematin is the "X factor" required to grown Haemophilus influenzae.
EC Number 240-140-1
Format powder
MDL # MFCD00010726
Molecular Formula C34H32ClFeN4O4
Personal Protective Equipment Eyeshields, Gloves,respirator filter
Physical Appearance Black Powder
Preparation Method Typically prepared by heating a hemoglobin solution with acetic acid and sodium chloride.
Product Families Description Hemin
Product Overview Hemin Chloride
Source Porcine
Storage and Handling Store at +4°C; protect from light.
Usage Statement Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.