Dino

Calmodulin

Calmodulin

Synonyms Phosphodiesterase 3,5'-cyclic-nucleotide activator; Calcium dependent regulator protein (CDR); Troponin C-Like peptide; CaM; calmodulin

CAS Number: 73298-54-1

EC Number: 277-370-7 MDL Number: MFCD00131869

Packaging size: 1 mg

SKU 0219569101
Price:
$500.20
In Stock
Request a quote
Description

Product Description

Calmodulin

Application Notes

Calmodulin is believed to be involved in intracellular Ca2+ homeostasis, cell proliferation, smooth muscle contraction, microtubular function, exocytotic secretion of cellular products, and cell motility. It may be used to activate CaM-dependent phosphodiesterase, calcineurin, CaM Kinases, etc. It is known to potentiate the hormonal stimulation of adenylate cyclase in the brain.

Usage Statement

Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Key Applications

Used to activate CaM-dependent phosphodiesterase||involved in intracellular Ca2+ homeostasis; cell proliferation; smooth muscle contraction; microtubular function; exocytotic secretion of cellular products; and cell motility.

Specifications
SKU 0219569101
Application Notes Calmodulin is believed to be involved in intracellular Ca2+ homeostasis, cell proliferation, smooth muscle contraction, microtubular function, exocytotic secretion of cellular products, and cell motility. It may be used to activate CaM-dependent phosphodiesterase, calcineurin, CaM Kinases, etc. It is known to potentiate the hormonal stimulation of adenylate cyclase in the brain.
Biochemical Physiological Actions Ca2+ binding protein that is required for activation of cyclic nucleotide-dependent phosphodiesterase. It is also a cofactor/activator of nitric oxide synthase, calcineurin, and many kinases including ATPase, myosin light chain kinase, and CAM kinase I, II, and III. It mediates ryanodine receptor activation by cyclic ADP ribose and is involved in intracellular Ca2+ homeostasis.
EC Number 277-370-7
Extinction Coefficient E1% (278 nm) = 1.8 (0.1 M Imidazole-HCl, 0.001 M EDTA, pH 7.0). If calcium is removed, E1% increases to 2.0.(Lit.)
Format powder
Formulation Details Lyophilized in 1.7 mM HEPES; pH 7.0; 30 µM CaCl2
Isoelectric Point 3.9-4.3 (Lit.)
Applications Used to activate CaM-dependent phosphodiesterase||involved in intracellular Ca2+ homeostasis; cell proliferation; smooth muscle contraction; microtubular function; exocytotic secretion of cellular products; and cell motility.
Pack Size 1 mg
Personal Protective Equipment Eyeshields, Gloves, respirator filter
Physical Appearance Powder
Product Families Description Calmodulin
Product Overview Calmodulin
Purity ≥99%
Source Bovine brain
Specific Activity ≥13,000 u/mg protein
Storage and Handling Store at -20 °C.
Unit Definition One unit will activate 3',5'-cyclic-nucleotide phosphodiesterase to 50% Vmax.
Usage Statement Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.