Wortmannin

Wortmannin

Synonyms [1s-(1a,6ba,9ab,11a,11bb)]-11-(Acetyloxy)-1,6b,7,8,9a,10,11,11b-octahydro-1-(methoxymethyl)-7,9,a,11b-dimethyl-3-furo (4,3,2-de)indeno[4,5,-h]-2-benzopyran-3,6,9-trione; KY 12420

CAS Number: 19545-26-7 Molecular Formula: C23H24O8 Molecular Weight: 428.437 g/mol

Beilstein Registry Number: 67676 MDL Number: MFCD00133927

Configure Your Product:

SKU 02195690-CF
Price:
$85.55
In Stock
Request a quote
Description

Product Description

Wortmannin

Application Notes

Wortmannin is a commonly used cell biology reagent that has been used previously in research to inhibit DNA repair, receptor-mediated endocytosis and cell proliferation. It inhibits fMLP induced PIP3 and superoxide anion production in guinea pig neutrophils. It blocks insulin metabolic effects in rat adipocytes without affecting the insulin receptor tyrosine kinase activity.

Usage Statement

Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Key Applications

Phosphatidylinositol 3-kinase (PI3-K) inhibitor

Specifications
SKU 02195690-CF
Alternate Names [1s-(1a,6ba,9ab,11a,11bb)]-11-(Acetyloxy)-1,6b,7,8,9a,10,11,11b-octahydro-1-(methoxymethyl)-7,9,a,11b-dimethyl-3-furo (4,3,2-de)indeno[4,5,-h]-2-benzopyran-3,6,9-trione; KY 12420
Application Notes Wortmannin is a commonly used cell biology reagent that has been used previously in research to inhibit DNA repair, receptor-mediated endocytosis and cell proliferation. It inhibits fMLP induced PIP3 and superoxide anion production in guinea pig neutrophils. It blocks insulin metabolic effects in rat adipocytes without affecting the insulin receptor tyrosine kinase activity.
Beilstein Registry Number 67676
Biochemical Physiological Actions Wortmannin is a potent and specific phosphatidylinositol 3-kinase (PI3-K) inhibitor. Inhibition of PI3-K/Akt signal transduction cascade enhances the apoptotic effects of radiation or serum withdrawal and blocks the antiapoptotic effect of cytokines. Inhibition of PI3-K by wortmannin also blocks many of the short-term metabolic effects induced by insulin receptor activation.
Format powder
Hazard Statements H300-H310-H330
Applications Phosphatidylinositol 3-kinase (PI3-K) inhibitor
MDL # MFCD00133927
Molecular Formula C23H24O8
Molecular Weight 428.437 g/mol
Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator, Gloves, respirator cartridge, respirator filter
Physical Appearance Off White Powder
Product Families Description Wortmannin
Product Overview Wortmannin
RTECS Number CB9641000
Safety Symbol GHS06
Source Penicillium wortmannii
Storage and Handling Store at -20°C; desiccate.
Usage Statement Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.