(±)-Verapamil Hydrochloride

(±)-Verapamil Hydrochloride

Synonyms Isoptin; 5-((3,4-Dimethoxyphenethyl)methylamino)-2-(3,4-Dimethoxyphenyl)-2-isopropylvaleronitrile; Iproveratril; 5-[N-(3,4-Dimethoxyphenylethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile hydrochloride; α-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-α-(1-methylethyl) benzeneacetonitrile; α-isopropyl-α-[(N-methyl-N-homoveratryl)-?-aminopropyl]-3,4-dimethoxyphenylacetonitrile

CAS Number: 152-11-4 Molecular Formula: C27H38N2O4·HCl

Beilstein Registry Number: 3647093 EC Number: 205-800-5 MDL Number: MFCD00055208

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SKU 02195545-CF
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Description

Product Description

(±)-Verapamil Hydrochloride

Application Notes

(±)-Verapamil hydrochloride is a calcium channel (L-type) modulator, adrenoceptor antagonist, anti-arrhythmic, cardiac depressant, and coronary vasodilator. It is also a calcium channel-blocker. It acts by inhibiting the slow channel entry of calcium into the cell. It acts by plugging up the channels and limiting the entry of calcium into both smooth muscle cells of arteriolar walls and the ardiac muscle cells at higher doses.

Usage Statement

Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.

Key Applications

Coronary vasodilator

Specifications
SKU 02195545-CF
Alternate Names Isoptin; 5-((3,4-Dimethoxyphenethyl)methylamino)-2-(3,4-Dimethoxyphenyl)-2-isopropylvaleronitrile; Iproveratril; 5-[N-(3,4-Dimethoxyphenylethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile hydrochloride; α-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-α-(1-methylethyl) benzeneacetonitrile; α-isopropyl-α-[(N-methyl-N-homoveratryl)-?-aminopropyl]-3,4-dimethoxyphenylacetonitrile
Application Notes (±)-Verapamil hydrochloride is a calcium channel (L-type) modulator, adrenoceptor antagonist, anti-arrhythmic, cardiac depressant, and coronary vasodilator. It is also a calcium channel-blocker. It acts by inhibiting the slow channel entry of calcium into the cell. It acts by plugging up the channels and limiting the entry of calcium into both smooth muscle cells of arteriolar walls and the ardiac muscle cells at higher doses.
Beilstein Registry Number 3647093
Biochemical Physiological Actions Blocks L-type Ca2+ channels in smooth and cardiac muscle, induces apoptosis of human primary and metastatic colon adenocarcinoma cells in vitro. Drug resistance reversal agent acting on Pgp, e.g. decrease renal tubule elimination of digoxin. Increases basal ATPase activity of Pgp. Substrate of Cyp3A4 and CYP2C6.
EC Number 205-800-5
Extinction Coefficient EmM = 16.1 (232 nm in ethanol); 6.1 (280 nm in ethanol)(Lit.)
Format powder
Hazard Statements H301-H311-H331
Applications Coronary vasodilator
MDL # MFCD00055208
Molecular Formula C27H38N2O4·HCl
Personal Protective Equipment Eyeshields, Faceshields, Gloves, Respirator cartridge
Physical Appearance White Powder
pKa 8.6 (Lit.)
Product Families Description (±)-Verapamil
Product Overview (±)-Verapamil Hydrochloride
RTECS Number YV8320000
Safety Symbol GHS06
Storage and Handling Store at Room Temperature (15-30 °C).
Usage Statement Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.