Trimethoprim is primarily used as an antibacterial agent. It has dihydrofolate reductase inhibitor activity with selectivity for the prokaryote enzyme. It is used to treat urinary tract infections, mild acute prostatitis, recurrent cystitis, asymptomatic bacteriuria during pregnancy and respiratory tract infections.
Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
|Alternate Names||2,4-Diamino-5-[3,4,5-trimethoxybenzyl]pyrimidine; 5-[(3,4,5-Trimethoxyphenyl) methyl]-2,4-pyrimidinediamine|
|Application Notes||Trimethoprim is primarily used as an antibacterial agent. It has dihydrofolate reductase inhibitor activity with selectivity for the prokaryote enzyme. It is used to treat urinary tract infections, mild acute prostatitis, recurrent cystitis, asymptomatic bacteriuria during pregnancy and respiratory tract infections.|
|Base Catalog Number||195527|
|Beilstein Registry Number||625127|
|Biochemical Physiological Actions||The combination of trimethoprim and sulfamethoxazole interferes with the cellular metabolism of folic acid in the bacterial cell by blocking the biosynthesis of nucleotides. Trimethoprim binds to dihydrofolate reductase and inhibits the reduction of dihydrofolic acid (DHF) to tetrahydrofolic acid (THF). THF is an essential precursor in the thymidine synthesis pathway and interference with this pathway inhibits bacterial DNA synthesis.|
|Melting Point||390 to 397° F (NTP, 1992)|
|Molecular Weight||290.323 g/mol|
|Personal Protective Equipment||Eyeshields, Gloves, respirator filter|
|Physical Appearance||White powder|
|Product Families Description||Trimethoprim|
|Solubility||less than 1 mg/mL at 75° F (NTP, 1992)|
|Storage and Handling||+4 °C|