Trimethoprim

Trimethoprim

Synonyms 2,4-Diamino-5-[3,4,5-trimethoxybenzyl]pyrimidine; 5-[(3,4,5-Trimethoxyphenyl) methyl]-2,4-pyrimidinediamine

CAS Number: 738-70-5 Molecular Formula: C14H18N4O3 Molecular Weight: 290.323 g/mol

Beilstein Registry Number: 625127 EC Number: 212-006-2 MDL Number: MFCD00036761

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SKU 02195527-CF
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Description

Product Description

Trimethoprim

Application Notes

Trimethoprim is primarily used as an antibacterial agent. It has dihydrofolate reductase inhibitor activity with selectivity for the prokaryote enzyme. It is used to treat urinary tract infections, mild acute prostatitis, recurrent cystitis, asymptomatic bacteriuria during pregnancy and respiratory tract infections.

Usage Statement

Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Key Applications

Antibacterial

Specifications
SKU 02195527-CF
Alternate Names 2,4-Diamino-5-[3,4,5-trimethoxybenzyl]pyrimidine; 5-[(3,4,5-Trimethoxyphenyl) methyl]-2,4-pyrimidinediamine
Application Notes Trimethoprim is primarily used as an antibacterial agent. It has dihydrofolate reductase inhibitor activity with selectivity for the prokaryote enzyme. It is used to treat urinary tract infections, mild acute prostatitis, recurrent cystitis, asymptomatic bacteriuria during pregnancy and respiratory tract infections.
Beilstein Registry Number 625127
Biochemical Physiological Actions The combination of trimethoprim and sulfamethoxazole interferes with the cellular metabolism of folic acid in the bacterial cell by blocking the biosynthesis of nucleotides. Trimethoprim binds to dihydrofolate reductase and inhibits the reduction of dihydrofolic acid (DHF) to tetrahydrofolic acid (THF). THF is an essential precursor in the thymidine synthesis pathway and interference with this pathway inhibits bacterial DNA synthesis.
EC Number 212-006-2
Applications Antibacterial
MDL # MFCD00036761
Melting Point 390 to 397° F (NTP, 1992)
Molecular Formula C14H18N4O3
Molecular Weight 290.323 g/mol
Personal Protective Equipment Eyeshields, Gloves, respirator filter
Physical Appearance White powder
Product Families Description Trimethoprim
Product Overview Trimethoprim
RTECS Number UV8225000
Solubility less than 1 mg/mL at 75° F (NTP, 1992)
Storage and Handling +4 °C
Usage Statement Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.