Rifampin

Rifampin

Synonyms Rifamycin AMP; Rifampicin; 3-(4-Methylpiperazinyliminomethyl)rifamycin SV; Rifampicin

CAS Number: 13292-46-1 Molecular Formula: C43H58N4O12 Molecular Weight: 822.953 g/mol

Beilstein Registry Number: 5723476 EC Number: 236-312-0 MDL Number: MFCD00151389

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SKU 02195490-CF
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Description

Product Description

Rifampin

Application Notes

Rifampicin is used to treat Tuberculosis and Tuberculosis-related mycobacterial infections. It is widely used as an antipruritic agent in the autoimmune cholestatic liver disease, primary biliary cirrhosis (PBC). It has been shown to cause hepatitis.

Usage Statement

Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Key Applications

Antibiotic||Inhibitor of transcription initiation||Antipruritic agent

Specifications
SKU 02195490-CF
Alternate Names Rifamycin AMP; Rifampicin; 3-(4-Methylpiperazinyliminomethyl)rifamycin SV; Rifampicin
Application Notes Rifampicin is used to treat Tuberculosis and Tuberculosis-related mycobacterial infections. It is widely used as an antipruritic agent in the autoimmune cholestatic liver disease, primary biliary cirrhosis (PBC). It has been shown to cause hepatitis.
Beilstein Registry Number 5723476
Biochemical Physiological Actions Mode of Action: Inhibits initiation of RNA synthesis by binding to β-subunit of RNA polymerase. It Inhibits the assembly of DNA and protein into mature virus particles.
EC Number 236-312-0
Extinction Coefficient EmM (max absorbance, phosphate buffer,pH 7.38): 33.20 (237 nm); 32.10 (255 nm); 27.00 (334 nm);15.40 (475 nm)(Lit.)
Format powder
Hazard Statements H302-H315-H319-H335
Isoelectric Point 4.8(in water)(Lit.)
Applications Antibiotic||Inhibitor of transcription initiation||Antipruritic agent
Loss on Drying ≤2%
MDL # MFCD00151389
Melting Point 183 °C
Molecular Formula C43H58N4O12
Molecular Weight 822.953 g/mol
Optical Rotation [α]D25°=+10.6° (c=0.5% in CDCl3)(Lit.)
Personal Protective Equipment Dust mask, Eyeshields, Gloves
Physical Appearance Orange Powder
pKa pKa (in water):1.7 (4-hydroxyl group), 7.9 (4-piperazine nitrogen); in methylcellosolve-water (4:1): 3.6 (4-hydroxyl group), 6.7 (3-piperazine nitrogen)(Lit.)
Product Families Description Rifampin
Product Overview Rifampin
RTECS Number VJ7000000
Safety Symbol GHS07
Solubility <h5 class="minor-section-title">Water Solubility</h5>1400 mg/L (at 25 °C)
Storage and Handling Store at +4 °C.
Usage Statement Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
UV Visible Absorbance λ max (methanol): 237 - 239, 334 - 338, 475 - 479 nm
Vapor Pressure 3.1X10-34 mm Hg at 25 deg C /Estimated/