Pepstatin A can be used in conjunction with E64-d and Leupeptin A to inhibit the degradation of autophagic cargo inside autophagosomes.
Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.
|Application Notes||Pepstatin A can be used in conjunction with E64-d and Leupeptin A to inhibit the degradation of autophagic cargo inside autophagosomes.|
|Beilstein Registry Number||2201362|
|Biochemical Physiological Actions||Pepstatin A is an inhibitor of acid proteases (aspartyl peptidases). It forms a 1:1 complex with proteases such as pepsin, renin, cathepsin D, bovine chymosin, and protease B (Aspergillus niger). The inhibitor is highly selective and does not inhibit thiol proteases, neutral proteases, or serine proteases. Solubilized γ-secretase and retroviral protease are also inhibited by Pepstatin A. It has been used to characterize proteases from several sources.|
|Personal Protective Equipment||Eyeshields, Gloves,respirator filter|
|Physical Appearance||White Powder|
|Product Families Description||Pepstatin A|
|Product Overview||Pepstatin A|
|Storage and Handling||Store at -0 °C; protect from light.|
|Typical Working Concentration||Effective concentration is approximately 1 uM (0.5 to 1.0 ug/mL).|
|Usage Statement||Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.|