Muscimol

Muscimol

Synonyms 3-Hydroxy-5-aminomethylisoxazole; 5-Aminomethyl-3-hydroxy-isoxazole; 5-Aminomethyl-3-isoxazolol

CAS Number: 2763-96-4 Molecular Formula: C4H6N2O2 Molecular Weight: 114.104 g/mol

Beilstein Registry Number: 1618960 EC Number: 220-430-4 MDL Number: MFCD00057894

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SKU 02195336-CF
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Description

Product Description

Muscimol

Application Notes

Muscimol has been widely used to reversibly inactivate localized groups of neurons. It can also be used, in place of radioactive reagents and methods, to map the distribution of muscimol in the nervous system, as well as to detect the presence of GABAA receptors on cell surfaces. Muscimol was also reported to cause change in the water intake of the mice. In cultured rat oligodendrocytes, muscimol has been shown to lead to a reduction in intracellular Cl-content, cell shrinkage, and stimulated Na-K-2Cl cotransporter isoform 1 (NKCC1) activity. Muscimol (50 mM) has been utilized to probe the role of the p42/44 mitogenactivated protein kinase (MAPK) cascade in the development of cultured rat hypothalamic neurons.

Usage Statement

Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Key Applications

GABA-agonist

Specifications
SKU 02195336-CF
Alternate Names 3-Hydroxy-5-aminomethylisoxazole; 5-Aminomethyl-3-hydroxy-isoxazole; 5-Aminomethyl-3-isoxazolol
Application Notes Muscimol has been widely used to reversibly inactivate localized groups of neurons. It can also be used, in place of radioactive reagents and methods, to map the distribution of muscimol in the nervous system, as well as to detect the presence of GABAA receptors on cell surfaces. Muscimol was also reported to cause change in the water intake of the mice. In cultured rat oligodendrocytes, muscimol has been shown to lead to a reduction in intracellular Cl-content, cell shrinkage, and stimulated Na-K-2Cl cotransporter isoform 1 (NKCC1) activity. Muscimol (50 mM) has been utilized to probe the role of the p42/44 mitogenactivated protein kinase (MAPK) cascade in the development of cultured rat hypothalamic neurons.
Beilstein Registry Number 1618960
Biochemical Physiological Actions GABAA receptor agonist.
EC Number 220-430-4
Format powder
Hazard Statements H300
Applications GABA-agonist
MDL # MFCD00057894
Melting Point 347° F decomposes (EPA, 1998)
Molecular Formula C4H6N2O2
Molecular Weight 114.104 g/mol
Personal Protective Equipment Eyeshields, Faceshields, Gloves, Respirator cartridges
Physical Appearance Off-White Powder
Product Families Description Muscimol
Product Overview Muscimol
RTECS Number NY3325000
Safety Symbol GHS06
Solubility In <a class="pubchem-internal-link CID-962" href="https://pubchem.ncbi.nlm.nih.gov/compound/water">water</a>, 5.67X10+5 mg/L (est)
Storage and Handling Store at -0 °C.
Usage Statement Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Vapor Pressure 2.94X10-4 mm Hg at 25 deg C (est)