Guanosine-5′-Triphosphate Disodium Salt

Guanosine-5′-Triphosphate Disodium Salt

Synonyms GTP disodium salt; 5′-GTP-Na2

CAS Number: 36051-31-7 Molecular Formula: C10H14N5O14P3Na2 Molecular Weight: 589.126 g/mol

EC Number: 259-940-7

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SKU 02195213-CF
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Description

Product Description

Guanosine-5′-Triphosphate Disodium Salt

Application Notes

Guanosine 5′-triphosphate (GTP), a purine trinucleotide, is a substrate for RNA polymerases and a wide range of GTPase including G-protein coupled receptor (GPCR) GTPases and cell signaling and cycling associated guanine nucleotide exhange factors (GEF).

Usage Statement

Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Key Applications

Substrate for RNA polymerases

Specifications
SKU 02195213-CF
Alternate Names GTP disodium salt; 5′-GTP-Na2
Application Notes Guanosine 5′-triphosphate (GTP), a purine trinucleotide, is a substrate for RNA polymerases and a wide range of GTPase including G-protein coupled receptor (GPCR) GTPases and cell signaling and cycling associated guanine nucleotide exhange factors (GEF).
Biochemical Physiological Actions GTP functions as a carrier of phosphates and pyrophosphates involved in channeling chemical energy into specific biosynthetic pathways. GTP activates the signal transducing G proteins which are involved in various cellular processes including proliferation, differentiation, and activation of several intracellular kinase cascades. Proliferation and apoptosis are regulated in part by the hydrolysis of GTP by small GTPases Ras and Rho. Another type of small GTPase, Rab, plays a role in the docking and fusion of vesicles and may also be involved in vesicle formation. In addition to its role in signal transduction, GTP also serves as an energy-rich precursor of mononucleotide units in the enzymatic biosynthesis of DNA and RNA.
EC Number 259-940-7
Format powder
Applications Substrate for RNA polymerases
Molecular Formula C10H14N5O14P3Na2
Molecular Weight 589.126 g/mol
Optical Rotation [α]20/D -24±2°, c = 1% in 0.5 M Na2HPO4
Personal Protective Equipment Eyeshields, Faceshields, Gloves, Respirator filter
Physical Appearance White Powder
Product Families Description Guanosine-5'-triphosphate
Product Overview Guanosine-5′-Triphosphate Disodium Salt
Purity ≥95%
Storage and Handling 0°C; desiccate
Usage Statement Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
UV Visible Absorbance λ max (water): 252 ± 3 nm