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Gossypol-Acetic Acid

Gossypol-Acetic Acid

Synonyms (±)-Gossypol-acetic acid; (+/–) Gossypol acetate

CAS Number: 12542-36-8 Molecular Formula: C30H30O8·C2H4O2 Molecular Weight: 578.614 g/mol

MDL Number: MFCD00058385

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SKU 02195211-CF
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Description

Product Description

Gossypol-Acetic Acid

Application Notes

In a study on the apoptotic effect of gossypol on human lymphocytes, gossypol was used at 20-50 mM to induce apoptosis in human lymphocytes without causing necrosis through cytotoxic effects. The combined use of steroid hormones (methyltestosterone and ethinyl estradiol) and gossypol (low dose) in an antifertility study in rats showed that the steroid hormone made the procedure of spermatogenesis slower and low dose gossypol caused all sperm to lose their activity in the epididymis. Both affect the process of spermatogenesis from different endpoints and successfully induce infertility in the short term. A low dose of gossypol not only executes antifertility function in the epididymis, but also affects the quality of spermatozoal production in testis by impacting the procedures of both acrosomal formation and spermatozoal elongation. This assists in maintaining long term infertility. Gossypol, as a PAF antagonist/inhibitor, markedly inhibited the contractile responses of guinea-pig lung parenchyma strips stimulated with leukotriene B4, leukotriene D4, and PAF-acether. It was suggested that the inhibition of the myotropic activity of the lung parenchyma by gossypol is due to interactions with the formation of cyclooxygenase products within the guinea-pig lung. Inhibits the autolytic conversion of pepsinogen to pepsin.

Usage Statement

Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Key Applications

PAF antagonist/inhibitor

Specifications
SKU 02195211-CF
Application Notes In a study on the apoptotic effect of gossypol on human lymphocytes, gossypol was used at 20-50 mM to induce apoptosis in human lymphocytes without causing necrosis through cytotoxic effects. The combined use of steroid hormones (methyltestosterone and ethinyl estradiol) and gossypol (low dose) in an antifertility study in rats showed that the steroid hormone made the procedure of spermatogenesis slower and low dose gossypol caused all sperm to lose their activity in the epididymis. Both affect the process of spermatogenesis from different endpoints and successfully induce infertility in the short term. A low dose of gossypol not only executes antifertility function in the epididymis, but also affects the quality of spermatozoal production in testis by impacting the procedures of both acrosomal formation and spermatozoal elongation. This assists in maintaining long term infertility. Gossypol, as a PAF antagonist/inhibitor, markedly inhibited the contractile responses of guinea-pig lung parenchyma strips stimulated with leukotriene B4, leukotriene D4, and PAF-acether. It was suggested that the inhibition of the myotropic activity of the lung parenchyma by gossypol is due to interactions with the formation of cyclooxygenase products within the guinea-pig lung. Inhibits the autolytic conversion of pepsinogen to pepsin.
Biochemical Physiological Actions The toxicity of gossypol is shown against the reproductive system, heart, liver, and membranes. The compound exhibits both pro- and anti-oxidant behavior. Electron transfer (ET) functionalities, present in gossypol and its metabolites, comprise conjugated dicarbonyl, a quinone derivative, Schiff bases, and metal complexes. The parent possesses a reduction potential favorable for in vivo ET. Considerable evidence points to oxidative stress, formation of a reactive oxygen species, and DNA scission, characteristics of redox cycling by ET in biosystems, as mechanism of action for gossypol. Reported to inhibit the autolytic conversion of pepsinogen to pepsin.
Format powder
Hazard Statements H302-H351
Applications PAF antagonist/inhibitor
Molecular Formula C30H30O8·C2H4O2
Molecular Weight 578.614 g/mol
Personal Protective Equipment Eyeshields, full-face particle respirator, Gloves, respirator cartridge, respirator filter
Physical Appearance Yellow Powder
Product Families Description Gossypol acetic acid
Product Overview Gossypol-Acetic Acid
RTECS Number MD7360000
Safety Symbol GHS07, GHS08
Storage and Handling Store at +4 °C. Protect from light
Usage Statement Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.