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Deae-Dextran, Chloride Form

Deae-Dextran, Chloride Form

Synonyms DEAE-Dextran chloride form; Diethylaminoethyl-dextran chloride form

CAS Number: 9015-73-0

MDL Number: MFCD00081561

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SKU 02195133-CF
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Description

Product Description

Deae-Dextran, Chloride Form

Application Notes

DEAE-Dextran is used in the development of sustained release protein delivery and nucleic acid transfection systems. The use of DEAE-Dextran as an efficient adjuvant in vaccine production is well established. For instance, DEAE-Dextran has been used for immunization of guinea pigs and swine with inactivated foot-and-mouth disease and rhesus monkeys with inactivated Venezulean equine encephalomyelitis virus, IVEE. The mechanism of action of DEAE-Dextran is not clear. The effect on the humoral response of rhesus monkeys to IVEE vaccine results in a typical IgM-IgG response. It has been speculated that DEAE-Dextran may cause a stimulation of the helper T-cell function in antibody synthesis.

Usage Statement

Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Key Applications

Enhances the uptake of proteins and nucleic acids into cells

Specifications
SKU 02195133-CF
Application Notes DEAE-Dextran is used in the development of sustained release protein delivery and nucleic acid transfection systems. The use of DEAE-Dextran as an efficient adjuvant in vaccine production is well established. For instance, DEAE-Dextran has been used for immunization of guinea pigs and swine with inactivated foot-and-mouth disease and rhesus monkeys with inactivated Venezulean equine encephalomyelitis virus, IVEE. The mechanism of action of DEAE-Dextran is not clear. The effect on the humoral response of rhesus monkeys to IVEE vaccine results in a typical IgM-IgG response. It has been speculated that DEAE-Dextran may cause a stimulation of the helper T-cell function in antibody synthesis.
Biochemical Physiological Actions DEAE-Dextran shows several important effects on cellular systems such as stimulates uptake of proteins and polynucleotides into cells, increases susceptibility of cells in culture to infection by viral RNA and DNA, increases sensitivity of viral plaque assays, inhibits growth of tumors in experimental animals, enhances antibody response in animals, stimulates interferon production induced by poly(I)-poly(C).
Format Powder; Chloride Form
Applications Enhances the uptake of proteins and nucleic acids into cells
Loss on Drying ≤10%
Personal Protective Equipment Eyeshields, Gloves, Respirator filter
Physical Appearance Off-white Powder
Preparation Method Prepared from Dextran MW: 500,000
Product Families Description DEAE-Dextran
Product Overview Deae-Dextran, Chloride Form
Sterilization of Solutions Solutions can be sterilized by autoclaving even at low pH. Autoclaving can be done at 110-115 °C. For 20% (w/v) or less solutions autoclave for approximately 30 minutes; for solutions above 20%, autoclave for approximately 15 minutes. Cool slowly.
Storage and Handling Store at Room Temperature (15 - 30 °C).
Usage Statement Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.