Dino

Amphotericin B

Amphotericin B

Synonyms Amphomoronal; Amphotericine B; Amphozone; Fungilin; Fungisone; Fungizone

CAS Number: 1397-89-3 Molecular Formula: C47H73NO17 Molecular Weight: 924.091 g/mol

Beilstein Registry Number: 78342 EC Number: 215-742-2 MDL Number: MFCD00877763

Configure Your Product:

SKU 02195043-CF
Price:
$54.00
In Stock
Request a quote
Description

Product Description

Amphotericin B

Application Notes

Amphotericin B is used to study the affects of the influx of calcium on antifungal activity and to study the binding and kinetics of Amphotericin B to sterols in monolayers, aqueous solutions, and phospholipid bilayers . It is also commonly used in tissue culture as an antifungal supplement.

Usage Statement

Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.

Key Applications

Antibiotic

Specifications
SKU 02195043-CF
Application Notes Amphotericin B is used to study the affects of the influx of calcium on antifungal activity and to study the binding and kinetics of Amphotericin B to sterols in monolayers, aqueous solutions, and phospholipid bilayers . It is also commonly used in tissue culture as an antifungal supplement.
Beilstein Registry Number 78342
Biochemical Physiological Actions Amphotericin B is a polyene antifungal antibiotic from Streptomyces. It has an affinity for sterols, primarily ergosterols, of fungal cell membranes. It forms channels in the membranes, causing small molecules to leak out which contributes to cell death. Antimicrobial spectrum: fungi and yeast. Polyene antifungal antibiotic from Streptomyces. Affinity for sterols, primarily ergosterols, of fungal cell membranes. Forms channels in the membranes, causing small molecules to leak out. Antimicrobial spectrum: fungi and yeast
EC Number 215-742-2
Hazard Statements H315-H319-H335
Applications Antibiotic
Melting Point greater than 338° F (decomposes) (NTP, 1992)
Molecular Formula C47H73NO17
Molecular Weight 924.091 g/mol
Personal Protective Equipment dust mask , Eyeshields, Gloves
Physical Appearance Yellow Powder
pKa 5.5 and 10.0.(Lit.)
Potency >800 µg/mg
Product Families Description Amphotericin B
Product Overview Amphotericin B
RTECS Number BU2625000
Safety Symbol GHS07
Solubility less than 1 mg/mL at 70° F (NTP, 1992)
Source Streptomyces sp.
Sterilization of Solutions Sterilization of solutions should be by filtration through teflon membrane filters; Amphotericin B should not be gamma irradiated or autoclaved.
Storage and Handling +4°C; desiccate; protect from light
Typical Working Concentration recommended concentration of 2.5 ug/L (prepared solution use 10 mL/L)
Usage Statement Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.