Tris

Tris

Synonyms Trometamol; Tromethamine; Tris-[hydroxymethyl]amino- methane; THAM; 2-Amino-2-(hydroxymethyl)- 1,3-propandiol; THAM; Tris base

CAS Number: 77-86-1 Molecular Formula: C4H11NO3 Molecular Weight: 121.136 g/mol

Beilstein Registry Number: 741883 EC Number: 201-064-4 MDL Number: MFCD00004679

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SKU 02194855-CF
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Description

Product Description

Tris

Application Notes

Tris has been useful as buffers in a wide variety of biological systems. Uses include pH control in vitro and in vivo for body fluids and in buffering systems for electrophoresis applications. Tris has been used as a starting material for polymers, oxazolones (with carboxylic acids) and oxazolidines (with aldehydes). Tris does not precipitate calcium salts and is of value in maintaining solubility of manganese salts. It can be used for the direct standardization of a strong acid solution; the equivalence point can be determined either potentiometrically or by use of a suitable indicator such as 3-(4-Dimethylamino-1-naphthylazo)-4-methoxybenzenesulfonic acid. It is an auxiliary material in pharmaceutical science.

Usage Statement

Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.

Key Applications

Buffer||Used as a starting material for polymers; oxazolones (with carboxylic acids) and oxazolidines||Used in direct standardization of a strong acid solution

Specifications
SKU 02194855-CF
Alternate Names Trometamol; Tromethamine; Tris-[hydroxymethyl]amino- methane; THAM; 2-Amino-2-(hydroxymethyl)- 1,3-propandiol; THAM; Tris base
Application Notes Tris has been useful as buffers in a wide variety of biological systems. Uses include pH control in vitro and in vivo for body fluids and in buffering systems for electrophoresis applications. Tris has been used as a starting material for polymers, oxazolones (with carboxylic acids) and oxazolidines (with aldehydes). Tris does not precipitate calcium salts and is of value in maintaining solubility of manganese salts. It can be used for the direct standardization of a strong acid solution; the equivalence point can be determined either potentiometrically or by use of a suitable indicator such as 3-(4-Dimethylamino-1-naphthylazo)-4-methoxybenzenesulfonic acid. It is an auxiliary material in pharmaceutical science.
Beilstein Registry Number 741883
Boiling Point 219-220 deg C at 10 mm Hg
EC Number 201-064-4
Format Crystalline powder
Grade Molecular Biology Reagent
Hazard Statements H315-H319-H335
Applications Buffer||Used as a starting material for polymers; oxazolones (with carboxylic acids) and oxazolidines||Used in direct standardization of a strong acid solution
Loss on Drying ≤1%
MDL # MFCD00004679
Melting Point 171-172 deg C
Molecular Formula C4H11NO3
Molecular Weight 121.136 g/mol
Personal Protective Equipment Dust mask, Eyeshields, Gloves
pH pH of 0.1 molar aq soln = 10.4
Physical Appearance White Crystalline Powder
pKa 8.1 at 25 °C(Lit.)
Product Families Description Tris
Product Overview Tris
Purity ≥99.95%
RTECS Number TY2900000
Safety Symbol GHS07
Solubility 79.1 mg/mL in <a class="pubchem-internal-link CID-174" href="https://pubchem.ncbi.nlm.nih.gov/compound/ethylene%20glycol">ethylene glycol</a>; 26 mg/mL in <a class="pubchem-internal-link CID-887" href="https://pubchem.ncbi.nlm.nih.gov/compound/methanol">methanol</a>; 14.6 mg/mL in anhyd <a class="pubchem-internal-link CID-702" href="https://pubchem.ncbi.nlm.nih.gov/compound/ethanol">ethanol</a>; 22 mg/mL in 95% <a class="pubchem-internal-link CID-702" href="https://pubchem.ncbi.nlm.nih.gov/compound/ethanol">ethanol</a>; 14 mg/mL in <a class="pubchem-internal-link CID-6228" href="https://pubchem.ncbi.nlm.nih.gov/compound/dimethyl-formamide">dimethyl formamide</a>; 20 mg/mL in <a class="pubchem-internal-link CID-180" href="https://pubchem.ncbi.nlm.nih.gov/compound/acetone">acetone</a>; 0.5 mg/mL in <a class="pubchem-internal-link CID-8857" href="https://pubchem.ncbi.nlm.nih.gov/compound/ethyl%20acetate">ethyl acetate</a>; 0.4 mg/mL in olive oil; 0.1 mg/mL in <a class="pubchem-internal-link CID-8078" href="https://pubchem.ncbi.nlm.nih.gov/compound/cyclohexane">cyclohexane</a>; 0.05 mg/mL in <a class="pubchem-internal-link CID-6212" href="https://pubchem.ncbi.nlm.nih.gov/compound/chloroform">chloroform</a>; less than 0.05 mg/mL in <a class="pubchem-internal-link CID-5943" href="https://pubchem.ncbi.nlm.nih.gov/compound/carbon%20tetrachloride">carbon tetrachloride</a>
Sterilization of Solutions Tris solutions can be autoclaved (121 °C, 15 psi, 15 minutes) or sterile filtered.
Storage and Handling Store at Room Temperature (15-30 °C). Store dessicated.
Usage Statement Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.
UV Visible Absorbance OD 260 nm (5% aq soln) ≤0.1
Vapor Pressure 2.2X10-5 mm Hg at 25 deg C (est)