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Guanidine Hydrochloride

Guanidine Hydrochloride

Synonyms Aminomethanamidine hydrochloride; Aminoformamidine hydrochloride; Guanidinium chloride; Guanidium chloride

CAS Number: 50-01-1 Molecular Formula: CH5N3· HCl Molecular Weight: 95.53

Beilstein Registry Number: 3591990 EC Number: 200-002-3 MDL Number: MFCD00013026

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SKU 02194826-CF
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Description

Product Description

Guanidine hydrochloride consists of a networkof guanidinium cations and chloride anions linked by N–H•••Cl hydrogen bonds,it is a strong chaotropic agent. Guanidine HCl may agglomerate upon storage. It may appear as a free-flowing crystalline powder, a free flowing powder with solid material dispersed throughout, or a solid. The quality of the product does not appear to be affected and solutions prepared from the free-flowing and lumpy guanidine HCl appear identical.

Application Notes

Guanidine hydrochloride can be used as the first step in refolding proteins or enzymes into their active form. Urea and dithiothreitol (DTT) may also be necessary. Also used in the isolation of RNA.Guanidine hydrochloride is a strong chaotropic agent useful for the denaturation and subsequent refolding of protein, it can solubilize insoluble or denatured proteins such as inclusion bodies and be used for the recovery of periplasmic proteins.

Usage Statement

Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Key Applications

Chaotropic agent

Specifications
SKU 02194826-CF
Application Notes Guanidine hydrochloride can be used as the first step in refolding proteins or enzymes into their active form. Urea and dithiothreitol (DTT) may also be necessary. Also used in the isolation of RNA.Guanidine hydrochloride is a strong chaotropic agent useful for the denaturation and subsequent refolding of protein, it can solubilize insoluble or denatured proteins such as inclusion bodies and be used for the recovery of periplasmic proteins.
Beilstein Registry Number 3591990
Density 1.345 g/cm3 at 20 °C (Lit.)
EC Number 200-002-3
Grade Molecular Biology Reagent
Hazard Statements H302-H315-H319
Applications Chaotropic agent
Loss on Drying ≤1.0%
Melting Point 180-190 °C
Molecular Formula CH5N3· HCl
Molecular Weight 95.53
Personal Protective Equipment Dust mask type , Eyeshields, Faceshields, Gloves
pH 4-6 (6.0 M aq solution)
Physical Appearance White crystalline powder
Purity >99%
RTECS Number MF4300000
Safety Symbol GHS07
Solubility Clear, Colorless Solution(6.0 M aq soln).
Storage and Handling Room Temperature
Usage Statement Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.