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Glycine, Molecular Biology Reagent

Glycine, Molecular Biology Reagent

Synonyms Aminoacetic acid; Glycolixir; Hampshire Glycine; Gly; Aminoethanoic acid; Glycocoll; G

CAS Number: 56-40-6 Molecular Formula: C2H5NO2 Molecular Weight: 75.067 g/mol

Beilstein Registry Number: 635782 EC Number: 200-272-2 MDL Number: MFCD00008131

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SKU 02194825-CF
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Description

Product Description

Glycine

Application Notes

Glycine is commonly used in buffer solutions, in electrophoresis and preparative chromatography. A study of the folding of monoclonal antibodies in the presence of glycine and their subsequent purification has been published. The use of glycine in the purification of lipopolysaccharides, lipooligosaccharides, and lipid A has been reported. It is an amino acid for use in cell culture media development applications and existing media formulations. Glycine is commonly used as a component in Tris-glycine and Tris-glycine-SDS running buffers for polyacrylamide gel electrophoresis, a component of Towbin's transfer buffer for Western blots, a buffer substance in cryoenzymology, in osmotic pressure maintenance in isoelectric focusing of erythrocytes, salting-in effect in protein chemistry, and as a buffer component in the coupled phosphatase-kinase reaction for end labelling of restriction fragments. The growth requirements of various microorganisms is reported in the Handbook of Microbiology.

Usage Statement

Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.

Key Applications

Buffer component

Specifications
SKU 02194825-CF
Application Notes Glycine is commonly used in buffer solutions, in electrophoresis and preparative chromatography. A study of the folding of monoclonal antibodies in the presence of glycine and their subsequent purification has been published. The use of glycine in the purification of lipopolysaccharides, lipooligosaccharides, and lipid A has been reported. It is an amino acid for use in cell culture media development applications and existing media formulations. Glycine is commonly used as a component in Tris-glycine and Tris-glycine-SDS running buffers for polyacrylamide gel electrophoresis, a component of Towbin's transfer buffer for Western blots, a buffer substance in cryoenzymology, in osmotic pressure maintenance in isoelectric focusing of erythrocytes, salting-in effect in protein chemistry, and as a buffer component in the coupled phosphatase-kinase reaction for end labelling of restriction fragments. The growth requirements of various microorganisms is reported in the Handbook of Microbiology.
Beilstein Registry Number 635782
Biochemical Physiological Actions Glycine is a non-chiral amino acid that can be synthesized in the body from the amino acid serine by Serine Hydroxymethyltransferase. Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.
Density 1.1607 (NTP, 1992)
EC Number 200-272-2
Format powder
Grade Molecular biology reagent
Applications Buffer component
Loss on Drying ≤0.5%
Melting Point 451° F (NTP, 1992)
Molecular Formula C2H5NO2
Molecular Weight 75.067 g/mol
Personal Protective Equipment Dust mask, Eyeshields, Faceshields, Gloves
pH 0.2 molar soln in <a class="pubchem-internal-link CID-962" href="https://pubchem.ncbi.nlm.nih.gov/compound/water">water</a>: 4.0
Physical Appearance Powder
pKa 2.35 at 25 °C (Lit.)
Product Families Description Glycine
Product Overview Glycine
Purity ≥99%
RTECS Number MB7600000
Solubility greater than or equal to 100 mg/mL at 64° F (NTP, 1992)
Storage and Handling Store at Room Temperature (15-30 °C).
Usage Statement Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.