Staurosporine from Streptomyces sp. was used to induce cell death in MDCK, 293T, Vero, HeLa, and Swiss Webster primary macrophage cells. It was used to study the effect of caspase activation on human sperm quality.
Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.
|Alternate Names||Antibiotic AM-2282|
|Application Notes||Staurosporine from Streptomyces sp. was used to induce cell death in MDCK, 293T, Vero, HeLa, and Swiss Webster primary macrophage cells. It was used to study the effect of caspase activation on human sperm quality.|
|Beilstein Registry Number||1060573|
|Biochemical Physiological Actions||Potent inhibitor of phospholipid/calcium-dependent protein kinase. Inhibits the upregulation of VEGF expression in tumor cells.Partially reverses MDR, sensitizing cells with MDR phenotype to cytotoxic agents. Inhibits Pgp phosphorylation. However, functional significance of Pgp phosphorylation is ill defined.|
|Grade||Molecular biology reagent|
|Molecular Weight||466.541 g/mol|
|Personal Protective Equipment||Eyeshields, full-face particle respirator , Gloves, respirator cartridge, respirator filter|
|Physical Appearance||White film around the bottom of the vial|
|Product Families Description||Staurosporine|
|Storage and Handling||+4°C; protect from light|
|Usage Statement||Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.|