Phorbol 12-Myristate 13-Acetate

Phorbol 12-Myristate 13-Acetate

Synonyms Phorbol Myristate Acetate; Phorbol Acetate Myristate; PMA; TPA; 12-O-Tetradecanoyl-phorbol 13-acetate; 4β,9α,12β,13α,20-Pentahydroxytiglia-1,6-dien-3-one 12-tetradecanoate 13-acetate

CAS Number: 16561-29-8 Molecular Formula: C36H56O8 Molecular Weight: 616.836 g/mol

Beilstein Registry Number: 2407201 MDL Number: MFCD00036736

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SKU 02194804-CF
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Description

Product Description

Phorbol 12-Myristate 13-Acetate

Application Notes

PMA activates Ca2+- ATPase and potentiates forskolin-induced cAMP formation. It has been shown to inhibit apoptosis induced by the Fas antigen, but PMA induces apoptosis in HL-60 promyelocytic leukemia cells.

Usage Statement

Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Key Applications

Potent tumor promoter

Specifications
SKU 02194804-CF
Alternate Names Phorbol Myristate Acetate; Phorbol Acetate Myristate; PMA; TPA; 12-O-Tetradecanoyl-phorbol 13-acetate; 4β,9α,12β,13α,20-Pentahydroxytiglia-1,6-dien-3-one 12-tetradecanoate 13-acetate
Application Notes PMA activates Ca2+- ATPase and potentiates forskolin-induced cAMP formation. It has been shown to inhibit apoptosis induced by the Fas antigen, but PMA induces apoptosis in HL-60 promyelocytic leukemia cells.
Beilstein Registry Number 2407201
Biochemical Physiological Actions Potent tumor promoter; activates protein kinase C in vivo and in vitro.
Grade Molecular Biology Reagent
Hazard Statements H315
Applications Potent tumor promoter
MDL # MFCD00036736
Melting Point 162° F (NTP, 1992)
Molecular Formula C36H56O8
Molecular Weight 616.836 g/mol
Personal Protective Equipment Dust mask, Eyeshields, Gloves
Physical Appearance Colorless Material
Product Families Description Phorbol 12-myristate 13-acetate
Product Overview Phorbol 12-Myristate 13-Acetate
Purity ~99%
RTECS Number QH4377000
Safety Symbol GHS07
Solubility Practically insoluble (NTP, 1992)
Storage and Handling Store at -20 °C. Protect from light.
Usage Statement Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Vapor Pressure 1.8X10-17 mm Hg at 25 deg C (est)