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Tetracycline Hydrochloride

Tetracycline Hydrochloride

Synonyms Achromycin HCl; Polucycline HCl; [4S-(4a, 4aa, 5aa, 6b, 12aa)]- 4-(Dimethylamino)- 1, 4, 4a, 5, 5a, 6-11, 12a- octahydro-3, 6, 10, 12, 12a-pentahydroxy- 6- methyl-1, 11-dioxo-2-naphthacenecarboxamide hydrochloride; Achro; Achromycin;, Achromycin V;, Ala Tet; Ambracyn; Ambramicina; Bristaciclina; Cefracycline; Criseociclina; Cyclopar; Diocyclin; Helvecyclin; Hostacyclin; Imex; Mediletten; Mephacyclin; Panmycin; Partrex; Polycycline; Purocyclina; Quadracyclin; Remicyclin; Riocyclin; Ro-Cycline; Sanclomycine; Steclin; Sumycin; Supramycin; Sustamycin; Tefilin; Tetrabakat; Tetrabid; Tetrablet; Tetrabon; Tetrachel; Tetracompren; Tetracyn; Tetrakap; Tetralution; Tetramavan; Tetramycin; Tetrosol; Topicycline; Totomycin; Triphacyclin; Unicin; Vetquamycin-324

CAS Number: 64-75-5 Molecular Formula: C22H24N2O8·HCl Molecular Weight: 480.898 g/mol

Beilstein Registry Number: 3844873 EC Number: 200-593-8 MDL Number: MFCD00078142

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SKU 02194542-CF
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Description

Product Description

Tetracycline Hydrochloride

Application Notes

Tetracycline hydrochloride is used in tetracycline controlled gene expression systems (gene switches) such a the tet-on and tet-off systems.

Usage Statement

Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Key Applications

Used in tetracycline controlled gene expression systems

Specifications
SKU 02194542-CF
Application Notes Tetracycline hydrochloride is used in tetracycline controlled gene expression systems (gene switches) such a the tet-on and tet-off systems.
Beilstein Registry Number 3844873
Biochemical Physiological Actions Mode of Action: Inhibits protein synthesis (elongation) by preventing binding of aminoacyl-tRNA to the 30S subunit. Antimicrobial spectrum: Gram-negative and Gram-positive bacteria. Mode of Resistance: Loss of cell wall permeability.
EC Number 200-593-8
Extinction Coefficient EMm (220nm) = 13 (free base in 0.1 M HCl); EmM (268nm) = 18.04 (free base in 0.1 M HCl); EmM (355nm) = 13.32 (free base in 0.1 M HCl)(Lit.)
Format powder
Grade Cell culture reagent
Hazard Statements H315-H319-H335
Applications Used in tetracycline controlled gene expression systems
Melting Point 417° F (decomposes) (NTP, 1992)
Moisture Content ≤2%
Molecular Formula C22H24N2O8·HCl
Molecular Weight 480.898 g/mol
Optical Rotation -239 ° to -258 ° (c=0.01, 0.1 N HCl)
Personal Protective Equipment Dust mask, Eyeshields, Gloves
pH 3.0-7.0 /saturated solution/
Physical Appearance Yellow Powder
pKa pKa (50% aq DMF): 8.3, 10.2 (Lit.)
Potency ≥900 µg/mg
Product Families Description Tetracycline
Product Overview Tetracycline Hydrochloride
RTECS Number QI9100000
Safety Symbol GHS07
Solubility 50 to 100 mg/mL at 72° F (NTP, 1992)
Storage and Handling Store at -0 °C. Store Under Nitrogen. Protect from light.
Usage Statement Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
UV Visible Absorbance λ max (1N HCl) 219, 271, 357 ± 5 nm