Spectinomycin, Pentahydrate, Dihydrochloride

Spectinomycin, Pentahydrate, Dihydrochloride

Synonyms U18409AE; Actinospectacin; M141; Trobicin

CAS Number: 22189-32-8 Molecular Formula: C14H24N2O7 • 2HCl • 5H2O Molecular Weight: 495.344 g/mol

EC Number: 244-554-3 MDL Number: MFCD00150886

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SKU 02194540-CF
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Description

Product Description

Spectinomycin, Pentahydrate, Dihydrochloride

Application Notes

Specinomycin is used in cell culture applications, It is active against gram-negative bacteria.It has been shown to have a wide variety of uses, including treating acute gonorrheal urethritis and cervictis, to mark cell layers to monitor cell fate during leaf development, as a selection marker in plant related transformation systems for plant cells containing the marker gene Spcr, to study respiratory tract infections of cattle caused by Pasteurella multocida and Mannheimia haemolytica, and to generate plants deficient for the plastid-encoded RNA polymerase on MS-agar media. Spectinomycin also has use in amplification of low copy number plasmid carrying replicons.

Usage Statement

Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Key Applications

Antibiotic

Specifications
SKU 02194540-CF
Alternate Names U18409AE; Actinospectacin; M141; Trobicin
Application Notes Specinomycin is used in cell culture applications, It is active against gram-negative bacteria.It has been shown to have a wide variety of uses, including treating acute gonorrheal urethritis and cervictis, to mark cell layers to monitor cell fate during leaf development, as a selection marker in plant related transformation systems for plant cells containing the marker gene Spcr, to study respiratory tract infections of cattle caused by Pasteurella multocida and Mannheimia haemolytica, and to generate plants deficient for the plastid-encoded RNA polymerase on MS-agar media. Spectinomycin also has use in amplification of low copy number plasmid carrying replicons.
Biochemical Physiological Actions Mode of Action: Spectinomycin acts by inhibiting protein synthesis and elongation by binding to the bacterial 30S ribosomal subunit and interfering with peptidyl tRNA translocation.Mode of Resistance: A mutation in rpsE, the gene for ribosomal protein S5, prevents the binding of spectinomycin. Resistance is also conferred by the aminoglycoside-3'-adenyltransferase gene (aadA).Antimicrobial spectrum: Spectinomycin acts against gram-negative and gram-positive bacteria.
EC Number 244-554-3
Format powder
Grade Cell Culture Reagent
Applications Antibiotic
Loss on Drying <20%
MDL # MFCD00150886
Molecular Formula C14H24N2O7 • 2HCl • 5H2O
Molecular Weight 495.344 g/mol
Personal Protective Equipment Eyeshields, Gloves, respirator filter
Physical Appearance White Powder
Product Families Description Spectinomycin
Product Overview Spectinomycin, Pentahydrate, Dihydrochloride
RTECS Number WG7400000
Source Streptomyces species
Specific Activity 500 µg/mg
Storage and Handling Store at +4 °C
Typical Working Concentration recommended for use in cell culture applications at 7.5-20 mg/L
Usage Statement Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.