Polymyxin B Sulfate

Polymyxin B Sulfate

Synonyms Aerosporin

CAS Number: 1405-20-5 Molecular Formula: C55H96N16O13·2H2SO4 Molecular Weight: 1301.571 g/mol

EC Number: 215-774-7 MDL Number: MFCD00131991

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SKU 02194538-CF
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Description

Product Description

Polymyxin B Sulfate

Application Notes

It is used as a lipid A binding agent that induces pore formation in cell membranes and as immobilized (substrate bound) agent for removal of endotoxins. The product has been used clinically to treat infections of the urinary tract, meninges and blood stream caused by susceptible strains of Pseudomonas aeruginosa. It also has uses studying multidrug-resistant pathogens, as an immobilized agent for removal of endotoxins, and to induce pore formation in the membranes of cortex cells from excised sorghum roots.

Usage Statement

Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Key Applications

Antibiotic

Specifications
SKU 02194538-CF
Alternate Names Aerosporin
Application Notes It is used as a lipid A binding agent that induces pore formation in cell membranes and as immobilized (substrate bound) agent for removal of endotoxins. The product has been used clinically to treat infections of the urinary tract, meninges and blood stream caused by susceptible strains of Pseudomonas aeruginosa. It also has uses studying multidrug-resistant pathogens, as an immobilized agent for removal of endotoxins, and to induce pore formation in the membranes of cortex cells from excised sorghum roots.
Biochemical Physiological Actions Antibiotic with bactericidal action on E. coli. Binds to the lipid A portion of bacterial lipopolysaccharides. Induces pore formation in the membranes of cortex cells from excised sorghum roots. Mode of Action: Binds to and interferes with the permeability of the cytoplasmic membrane. Antimicrobial spectrum: Gram-negative bacteria.
EC Number 215-774-7
Format powder
Grade Cell Culture Reagent
Hazard Statements H302
Applications Antibiotic
Loss on Drying <8%
MDL # MFCD00131991
Molecular Formula C55H96N16O13·2H2SO4
Molecular Weight 1301.571 g/mol
Personal Protective Equipment Dust mask , Eyeshields, Gloves
Physical Appearance White Powder
Potency >6,000 u/mg
Product Families Description Polymixin-B-sulfate
Product Overview Polymyxin B Sulfate
RTECS Number TR1150000
Safety Symbol GHS07
Solubility Water Solubility25 mg/mL
Storage and Handling Store at + 4 °C.Store dessicated
Typical Working Concentration 50 mg/L
Usage Statement Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.