Mitomycin C

Mitomycin C

Synonyms Ametycin; 7-Amino-9-a-methoxymitosane; Mit-C; Mitocin-C; Mitomycinum; Mutamycin; Azirizino[2', 3': 3,4] pyrrolo [1,2-a] indole 4,7-dione-6-amino-1,1a, 2, 8, 8a, 8b-hexahydro- 8- (hydroxymethyl) 8a-methoxy-5-methyl carbamate

CAS Number: 50-07-7 Molecular Formula: C15H18N4O5 Molecular Weight: 334.332 g/mol

Beilstein Registry Number: 7231816 EC Number: 200-008-6 MDL Number: MFCD00078109

Packaging size: 2 mg

SKU 0219453202
Price:
$129.40
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Description

Product Description

Mitomycin C

Application Notes

Mitomycin C is the most widely used as Mitomycin antibiotics because it is the least toxic and with the most potent antitumor activity. It has extraordinarily strong activity against Ehrlich ascites tumor cells.It also possesses strong bactericidal action against Gram-positive and Gram-negative organisms and acid-fact bacilli. Mitomycin C is used to generate mitotically inactive feeder cells used in cell culture systems, such as mitotically inactive fibroblast used in embryonic stem cell (ESC) systems.

Usage Statement

Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Key Applications

Generate mitotically inactive feeder cells

Specifications
SKU 0219453202
Alternate Names Ametycin; 7-Amino-9-a-methoxymitosane; Mit-C; Mitocin-C; Mitomycinum; Mutamycin; Azirizino[2', 3': 3,4] pyrrolo [1,2-a] indole 4,7-dione-6-amino-1,1a, 2, 8, 8a, 8b-hexahydro- 8- (hydroxymethyl) 8a-methoxy-5-methyl carbamate
Application Notes Mitomycin C is the most widely used as Mitomycin antibiotics because it is the least toxic and with the most potent antitumor activity. It has extraordinarily strong activity against Ehrlich ascites tumor cells.It also possesses strong bactericidal action against Gram-positive and Gram-negative organisms and acid-fact bacilli. Mitomycin C is used to generate mitotically inactive feeder cells used in cell culture systems, such as mitotically inactive fibroblast used in embryonic stem cell (ESC) systems.
Beilstein Registry Number 7231816
Biochemical Physiological Actions Mode of Action: This product is an alkylating agent that specifically targets the guanine nucleoside sequence 5'-CpG-3'. It inhibits DNA synthesis by covalently reacting with DNA, forming crosslinks between complementary strands of DNA. This interaction prevents separation of complementary DNA strands, inhibiting DNA replication.Antimicrobial Spectrum: Mitomycin C has strong antitumor activity, especially against Ehrlich ascites tumor cells, and strong bactericidal action against gram-positive and gram-negative bacteria.
Boiling Point 534 °C
EC Number 200-008-6
Grade Cell Culture Reagent
Hazard Statements H302-H351
Applications Generate mitotically inactive feeder cells
MDL # MFCD00078109
Melting Point Above 680° F (EPA, 1998)
Molecular Formula C15H18N4O5
Molecular Weight 334.332 g/mol
Pack Size 2 mg
Physical Appearance Blue Powder
Product Families Description Mitomycin C
Product Overview Mitomycin C
RTECS Number CN0700000
Safety Symbol GHS07, GHS08
Solubility Soluble (NTP, 1992)
Storage and Handling Store at + 4 °C.
Usage Statement Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.