Cycloheximide

Cycloheximide

Synonyms Acti-Dione; 3-[2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl] glutarimide; Naramycin A; Actidione; CHX

CAS Number: 66-81-9 Molecular Formula: C15H23NO4 Molecular Weight: 281.352 g/mol

Beilstein Registry Number: 88868 EC Number: 200-636-0 MDL Number: MFCD00082346

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SKU 02194527-CF
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Description

Product Description

Cycloheximide

Application Notes

Cycloheximide is used in plant research to study disease resistance and as an ethylene stimulant, useful in studies involving fruit and leaf production. It is also used in bacteriological media to isolate or count bacteria in the presence of yeast and molds; Used in protein synthesis in apoptosis; Gene expression; Glycogenolysis, gluconeogenesis and ureogenesis in isolated rat hepatocytes; Studies involving steroidogenesis; Used in plant regulation and as a quality control measure by the food and beverage industry.

Usage Statement

Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.

Key Applications

Antibiotics||Antifungal

Specifications
SKU 02194527-CF
Alternate Names Acti-Dione; 3-[2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl] glutarimide; Naramycin A; Actidione; CHX
Application Notes Cycloheximide is used in plant research to study disease resistance and as an ethylene stimulant, useful in studies involving fruit and leaf production. It is also used in bacteriological media to isolate or count bacteria in the presence of yeast and molds; Used in protein synthesis in apoptosis; Gene expression; Glycogenolysis, gluconeogenesis and ureogenesis in isolated rat hepatocytes; Studies involving steroidogenesis; Used in plant regulation and as a quality control measure by the food and beverage industry.
Beilstein Registry Number 88868
Biochemical Physiological Actions Cycloheximide (CHX) is an antibiotic produced by S. griseus. Its main biological activity is translation inhibition in eukaryotes resulting in cell growth arrest and cell death. CHX is widely used for selection of CHX-resistant strains of yeast and fungi, controlled inhibition of protein synthesis for detection of short-lived proteins and super-induction of protein expression, and apoptosis induction or facilitation of apoptosis induction by death receptors. Cycloheximide is inhibits peptide synthesis in eukaryotic organisms but not in prokaryotes. Protein synthesis is blocked by the interaction of cycloheximide with the translocase enzyme. This interaction prohibits the translocation of messenger RNA on the cytosolic, 80S ribosomes without inhibiting organelle protein synthesis. Cycloheximide is also known to induce FAS/FAS Ligand apoptosis, and triggers apoptosis in HL-60 cells, T-cell hybridomas, Burkitt's lymphoma cells in addition to a variety of other cell types. Cycloheximide will also delay or inhibit apoptosis induced by other agents.
EC Number 200-636-0
Format powder
Grade Cell Culture Reagent
Hazard Statements H300-H341-H360D-H411
Applications Antibiotics||Antifungal
MDL # MFCD00082346
Melting Point 247 to 250° F (EPA, 1998)
Molecular Formula C15H23NO4
Molecular Weight 281.352 g/mol
Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator, Gloves, Respirator cartridge
Physical Appearance White Powder
Product Families Description Cycloheximide
Product Overview Cycloheximide
RTECS Number MA4375000
Safety Symbol GHS06, GHS08, GHS09
Solubility 10 to 50 mg/mL at 68° F (NTP, 1992)
Storage and Handling +4 °C
Usage Statement Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.