Actinomycin D
Description
Product Description
Actinomycin D
Application Notes
Actinomycin D is an antineoplastic antibiotic that inhibits cell proliferation with wide-ranging applications ranging from a selection agent in cell culture, use in studies of suppressing HIV-replication and programmed cell death of PC12 cells, and as an antibiotic in treatment of various malignant neoplasms, including Wilm's tumour and the sarcomas.
Usage Statement
Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.
Key Applications
Antibiotic
Specifications
| SKU | 02194525-CF |
| Alternate Names | Dactinomycin; Actinomycin D; actinomycin-[thr-val-pro-sar-meval]; meractinomycin; actinomycin AIV; actinomycin IV; actinomycin C1; actinomycin X1; NSC-3053; Cosmegen |
| Application Notes | Actinomycin D is an antineoplastic antibiotic that inhibits cell proliferation with wide-ranging applications ranging from a selection agent in cell culture, use in studies of suppressing HIV-replication and programmed cell death of PC12 cells, and as an antibiotic in treatment of various malignant neoplasms, including Wilm's tumour and the sarcomas. |
| Biochemical Physiological Actions | Actinomycin D inhibits the proliferation of cells by forming a stable complex with double-stranded DNA, inhibiting DNA-primed RNA synthesis and causing single-stranded breaks in DNA. It has been shown to be an inhibitor of the minus-strand transfer step in reverse transcriptase. |
| EC Number | 200-063-6 |
| Format | Crystalline |
| Grade | Cell Culture Reagent |
| Hazard Statements | H300 |
| Applications | Antibiotic |
| MDL # | MFCD00005033 |
| Melting Point | 467 to 469° F (decomposes) (NTP, 1992) |
| Molecular Formula | C62H86N12O16 |
| Molecular Weight | 1255.438 g/mol |
| Personal Protective Equipment | Eyeshields, Faceshields, full-face particle respirator, Gloves, respirator cartridge |
| Physical Appearance | Red Powder |
| Product Families Description | Actinomycin D |
| Product Overview | Actinomycin D |
| Purity | ~98% |
| Refractive Index | 1.656(lit.) |
| RTECS Number | AU1575000 |
| Safety Symbol | GHS06 |
| Solubility | Soluble at 50° F (NTP, 1992) |
| Storage and Handling | Store at +4 °C; protect from light. |
| Typical Working Concentration | cell culture applications at 1µg/mL. |
| Usage Statement | Research Use Only (RUO). Ready for CE IVD labeling of clinical applications. |
| Vapor Pressure | 0 mm Hg at 25 deg C (est) |