Dino

Actinomycin D

Actinomycin D

Synonyms Dactinomycin; Actinomycin D; actinomycin-[thr-val-pro-sar-meval]; meractinomycin; actinomycin AIV; actinomycin IV; actinomycin C1; actinomycin X1; NSC-3053; Cosmegen

CAS Number: 50-76-0 Molecular Formula: C62H86N12O16 Molecular Weight: 1255.438 g/mol

EC Number: 200-063-6 MDL Number: MFCD00005033

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SKU 02194525-CF
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Description

Product Description

Actinomycin D

Application Notes

Actinomycin D is an antineoplastic antibiotic that inhibits cell proliferation with wide-ranging applications ranging from a selection agent in cell culture, use in studies of suppressing HIV-replication and programmed cell death of PC12 cells, and as an antibiotic in treatment of various malignant neoplasms, including Wilm's tumour and the sarcomas.

Usage Statement

Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.

Key Applications

Antibiotic

Specifications
SKU 02194525-CF
Application Notes Actinomycin D is an antineoplastic antibiotic that inhibits cell proliferation with wide-ranging applications ranging from a selection agent in cell culture, use in studies of suppressing HIV-replication and programmed cell death of PC12 cells, and as an antibiotic in treatment of various malignant neoplasms, including Wilm's tumour and the sarcomas.
Biochemical Physiological Actions Actinomycin D inhibits the proliferation of cells by forming a stable complex with double-stranded DNA, inhibiting DNA-primed RNA synthesis and causing single-stranded breaks in DNA. It has been shown to be an inhibitor of the minus-strand transfer step in reverse transcriptase.
EC Number 200-063-6
Format Crystalline
Grade Cell Culture Reagent
Hazard Statements H300
Applications Antibiotic
Melting Point 467 to 469° F (decomposes) (NTP, 1992)
Molecular Formula C62H86N12O16
Molecular Weight 1255.438 g/mol
Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator, Gloves, respirator cartridge
Physical Appearance Red Powder
Product Families Description Actinomycin D
Product Overview Actinomycin D
Purity ~98%
Refractive Index 1.656(lit.)
RTECS Number AU1575000
Safety Symbol GHS06
Solubility Soluble at 50° F (NTP, 1992)
Storage and Handling Store at +4 °C; protect from light.
Typical Working Concentration cell culture applications at 1µg/mL.
Usage Statement Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.
Vapor Pressure 0 mm Hg at 25 deg C (est)