Dino

Pyrimethamine

Pyrimethamine

Synonyms 5-[4-Chlorophenyl]-6-ethyl-2,4-pyrimidinediamine; 2,4-diamino-5-(p-chlorophenyl)-6-ethylpyrimidine; Chloridin

CAS Number: 58-14-0 Molecular Formula: C12H13N4Cl Molecular Weight: 248.714 g/mol

Beilstein Registry Number: 219864 EC Number: 200-364-2 MDL Number: MFCD00057350

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SKU 02194180-CF
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Description

Product Description

Pyrimethamine

Application Notes

Pyrimethamine is a medication used for protozoal infections. It is commonly used as an antimalarial drug, and is also used (combined with sulfadiazine) in the treatment of Toxoplasma gondii infections in immunocompromised patients, such as HIV-positive individuals. It is also currently being evaluated in clinical trials as a treatment for ALS.

Usage Statement

Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.

Key Applications

Antiprotozoal compound

Specifications
SKU 02194180-CF
Application Notes Pyrimethamine is a medication used for protozoal infections. It is commonly used as an antimalarial drug, and is also used (combined with sulfadiazine) in the treatment of Toxoplasma gondii infections in immunocompromised patients, such as HIV-positive individuals. It is also currently being evaluated in clinical trials as a treatment for ALS.
Beilstein Registry Number 219864
Biochemical Physiological Actions Pyrimethamine interferes with tetrahydrofolic acid synthesis from folic acid by inhibiting the enzyme dihydrofolate reductase (DHFR). Tetrahydrofolic acid is needed for DNA and RNA synthesis in many species, including protozoa. It has also found to inhibit SOD1, a key protein involved in ALS.
EC Number 200-364-2
Format powder
Hazard Statements H302
Applications Antiprotozoal compound
Melting Point 451 to 453° F (capillary) (NTP, 1992)
Molecular Formula C12H13N4Cl
Molecular Weight 248.714 g/mol
Personal Protective Equipment Dust mask, Eyeshields, Faceshields, Gloves
Physical Appearance White powder
Product Families Description Pyrimethamine
Product Overview Pyrimethamine
RTECS Number UV8140000
Safety Symbol GHS07
Solubility >37.3 [ug/mL]
Storage and Handling Store at Room Temperature(15-30 °C).
Usage Statement Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.
Vapor Pressure 1.32X10-8 mm Hg at 25 deg C (est)