Colistin Sulphate Salt
Product Description
Colistin Sulphate Salt
Application Notes
Colistin sulfate is used to permeabilize bacterial cell membranes and to study mannose-resistant haemagglutination and antibiotic resistance in certain organisms such as A. baumannii. It has been used to study hephrotoxicity in the rat kidney, and MICs, time-kill kinetics, and postantibiotic effect (PAE) against Pseudomonas aeruginosa.
Usage Statement
Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| SKU | 02194157-CF |
| Alternate Names | Polymyxin E |
| Application Notes | Colistin sulfate is used to permeabilize bacterial cell membranes and to study mannose-resistant haemagglutination and antibiotic resistance in certain organisms such as A. baumannii. It has been used to study hephrotoxicity in the rat kidney, and MICs, time-kill kinetics, and postantibiotic effect (PAE) against Pseudomonas aeruginosa. |
| Biochemical Physiological Actions | Mode of Action: Binds to lipids on the cell cytoplasmic membrane of Gram-negative bacteria and disrupts the cell wall integrity. Antimicrobial spectrum: Gram-negative bacteria. It is proposed that renal reabsorption of colistin may involve organic cation transporters and peptide transporters and that the process is sensitive to pH. |
| EC Number | 215-034-3 |
| Hazard Statements | H301 |
| MDL # | MFCD00146495 |
| Molecular Weight | 1253.527 g/mol |
| Personal Protective Equipment | Eyeshields, Faceshields, Gloves, respirator cartridges |
| Physical Appearance | Off-white powder |
| Product Families Description | Colistin |
| Product Overview | Colistin Sulphate Salt |
| RTECS Number | TR1500000 |
| Specific Activity | ≥15,000 u/mg |
| Storage and Handling | +4 °C; desiccate |
| Usage Statement | Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |