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Hemin Chloride

Hemin Chloride

Synonyms Hemin Chloride; Chloroferriprotoporphyrin; Chlorohemin; Chloro(protoprophyrinato) iron (III); Ferriprotoporphyrin IX chloride; Hematin hydrochloride; Protohemin IX; (SP-5-13)-Chloro [7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)- N21, N22, N23, N24] ferrate(2-) dihydrogen; Chloro [dihydrogen 3,7,12,17-tetramethyl-8,13-divinyl-2, 18-porphinedipropionato (2-)]iron; 1,3,5,8-tetramethyl-2,4-divinylporphine-6,7- dipropionic acid ferrichloride; Teichmann's crystals; Ferriheme chloride; Chloroprotoporphyrin IX iron(III)

CAS Number: 16009-13-5 Molecular Formula: C34H32ClFeN4O4

Beilstein Registry Number: 5229914 EC Number: 240-140-1 MDL Number: MFCD00010726

Packaging size: 1 g

SKU 0219402501
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Description

Product Description

Hemin Chloride

Application Notes

Hemin chloride, at a concentration of 20 mM demonstrated the significance of heme in myotube maturation by increasing size, number, cross-striations, and contraction frequency and strength of myotubes. The compound has been observed to induce cGMP formation through induction of guanylate cyclase. In the rat Hemin chloride has been noted to stimulate calcium dependent K+ channels along with control of fluid transport and Na+ in the loop of henle. Hemin has also been documented to give rise to active chloride secretion in Caco-2 cells. In cadmium injured rat testes Hemin chloride demonstrated anti-apoptotic, anti-inflamatory and antioxidant properties. Through reactive oxygen species of ERK-1/2-Elk-1 and NF-kappa B, Hemin chloride has been shown to upregulate Egr-1 expression in vascular smooth muscle cells. It has also been used in solution to prepare certain types of Agar medium for the cultivation of distinct bacteria. Hemin was used to study conjugation, characterization and toxicity of lipophosphoglycan-polyacrylic acid conjugate for vaccination against leishmaniasis.

Usage Statement

Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.

Key Applications

Stimulate calcium dependent K+ channels

Specifications
SKU 0219402501
Application Notes Hemin chloride, at a concentration of 20 mM demonstrated the significance of heme in myotube maturation by increasing size, number, cross-striations, and contraction frequency and strength of myotubes. The compound has been observed to induce cGMP formation through induction of guanylate cyclase. In the rat Hemin chloride has been noted to stimulate calcium dependent K+ channels along with control of fluid transport and Na+ in the loop of henle. Hemin has also been documented to give rise to active chloride secretion in Caco-2 cells. In cadmium injured rat testes Hemin chloride demonstrated anti-apoptotic, anti-inflamatory and antioxidant properties. Through reactive oxygen species of ERK-1/2-Elk-1 and NF-kappa B, Hemin chloride has been shown to upregulate Egr-1 expression in vascular smooth muscle cells. It has also been used in solution to prepare certain types of Agar medium for the cultivation of distinct bacteria. Hemin was used to study conjugation, characterization and toxicity of lipophosphoglycan-polyacrylic acid conjugate for vaccination against leishmaniasis.
Beilstein Registry Number 5229914
EC Number 240-140-1
Format powder
Grade Molecular biology reagent
Applications Stimulate calcium dependent K+ channels
Molecular Formula C34H32ClFeN4O4
Pack Size 1 g
Personal Protective Equipment Eyeshields, Gloves, Respirator filter
Physical Appearance Black Powder
Preparation Method Typically prepared by heating a hemoglobin solution with acetic acid and sodium chloride.
Product Families Description Hemin
Product Overview Hemin Chloride
Purity ≥95%
Source Bovine
Storage and Handling +4 °C. Protect from light.
Usage Statement Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.
UV Visible Absorbance λ max (0.1N NaOH): 380 - 387 nm