Chloroquine Diphosphate Salt

Chloroquine Diphosphate Salt

Synonyms Chloroquinone Phosphate;N4-(7-Chloro-4-quinolinyl)-N1,N1-dimethyl-1,4-pentanediamine diphosphate salt

CAS Number: 50-63-5 Molecular Formula: C18H26N3Cl • 2H3PO4 Molecular Weight: 515.865 g/mol

Beilstein Registry Number: 4223142 EC Number: 200-055-2 MDL Number: MFCD00069852

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SKU 02193919-CF
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Description

Product Description

Chloroquine Diphosphate Salt

Application Notes

Chloroquine diphosphate salt is used to study the role of endosomal acidification in cellular processes, such as the signaling of intracellular TLRs. It can be used as DNA intercalator & to dissociate antigen antibody complexes without denaturing red blood cell antigens. DNA intercalator. Also used to increase transfection efficiency.

Usage Statement

Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Specifications
SKU 02193919-CF
Alternate Names Chloroquinone Phosphate;N4-(7-Chloro-4-quinolinyl)-N1,N1-dimethyl-1,4-pentanediamine diphosphate salt
Application Notes Chloroquine diphosphate salt is used to study the role of endosomal acidification in cellular processes, such as the signaling of intracellular TLRs. It can be used as DNA intercalator & to dissociate antigen antibody complexes without denaturing red blood cell antigens. DNA intercalator. Also used to increase transfection efficiency.
Beilstein Registry Number 4223142
Biochemical Physiological Actions Standard anti-malarial drug. Substrate for MRP in multidrug resistant cell line and inhibits photoaffinity labeling of MRP by quinoline-based photoactive drug IAAQ (N-[4-[1-hydroxy-2-(dibutylamino)ethyl]quinolin-8-yl]-4-azidosalicylamide).
EC Number 200-055-2
Hazard Statements H302
MDL # MFCD00069852
Melting Point 87 deg C
Molecular Formula C18H26N3Cl • 2H3PO4
Molecular Weight 515.865 g/mol
Personal Protective Equipment Dust mask type , Eyeshields, Gloves
Physical Appearance Off-White Powder
pKa 4.0 - 5.0
Potency 8.4 and 10.8 (for chloroquine base at 20 °C)
Product Families Description Chloroquine diphosphate
Product Overview Chloroquine Diphosphate Salt
RTECS Number VB2450000
Solubility VERY SLIGHTLY SOL IN <a class="pubchem-internal-link CID-962" href="https://pubchem.ncbi.nlm.nih.gov/compound/WATER">WATER</a>; SOL IN DIL ACIDS, <a class="pubchem-internal-link CID-6212" href="https://pubchem.ncbi.nlm.nih.gov/compound/CHLOROFORM">CHLOROFORM</a>, ETHER
Source Soluble in water. Practically insoluble in alcohol; benzene; chloroform and ether.
Storage and Handling Room Temperature
Unit Definition Chloroquine showed very high antiviral activity against NiV but very little activity against the other viruses at concentrations lower than 20 µM
Usage Statement Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Vapor Pressure 5.0X10-9 mm Hg at 25 deg C (est)