Dino

Etoposide

Etoposide

Synonyms EPA; Demethyl-epiodophyllotoxin ethylidene glucoside; Vepesid; EPEG; VP-16; VP-16213; NK 171; NSC-141540; 4'-Demethylepipodophyllotoxin; 9-(4,6-O-Ethylidene-b-D-Glucopyranoside)

CAS Number: 33419-42-0 Molecular Formula: C29H32O13 Molecular Weight: 588.562 g/mol

EC Number: 251-509-1 MDL Number: MFCD00869325

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SKU 02193918-CF
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Description

Product Description

Etoposide

Application Notes

Etoposide inhibits DNA synthesis and is very active against cells in the late S and G2 phases of the cell cycle. Etoposide was reported to be used to serum starve Saos-2 M5(p53−/−) cells which were transfected by electroporation with indicated expression plasmids for flag-E2F1 and myc-EBNA3C for selection of colony forming units, thus studying the blocking effect of EBV Nuclear Antigen 3C on E2F1 Mediated Apoptosis Induced by the DNA Damage Response.

Usage Statement

Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Key Applications

Topoisomerase inhibitor

Specifications
SKU 02193918-CF
Application Notes Etoposide inhibits DNA synthesis and is very active against cells in the late S and G2 phases of the cell cycle. Etoposide was reported to be used to serum starve Saos-2 M5(p53−/−) cells which were transfected by electroporation with indicated expression plasmids for flag-E2F1 and myc-EBNA3C for selection of colony forming units, thus studying the blocking effect of EBV Nuclear Antigen 3C on E2F1 Mediated Apoptosis Induced by the DNA Damage Response.
Biochemical Physiological Actions Etoposide is an antitumor agent that complexes with topoisomerase II and DNA to enhance double-strand and single-strand cleavage of DNA and reversibly inhibit religation. Blocks the cell cycle in in S-phase and G2-phase of the cell cycle; induces apoptosis in normal and tumor cell lines; inhibits synthesis of the oncoprotein Mdm2 and induces apoptosis in tumor lines that overexpress Mdm2.
EC Number 251-509-1
Format powder
Hazard Statements H302-H350
Applications Topoisomerase inhibitor
Melting Point 236-251 °C
Molecular Formula C29H32O13
Molecular Weight 588.562 g/mol
Personal Protective Equipment Eyeshields, Full-face particle respirator, Gloves, Respirator cartridge, Respirator filter
Physical Appearance White Powder
pKa 9.8 (Lit.)
Product Families Description Etoposide
Product Overview Etoposide
RTECS Number KC0190000
Safety Symbol GHS07, GHS08
Solubility <h5 class="minor-section-title">Water Solubility</h5>Sparingly soluble
Storage and Handling Room Temperature
Usage Statement Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
UV Visible Absorbance λmax (methanol)
Vapor Pressure 5.4X10-23 mm Hg at 25 deg C /Estimated/