Insulin, Human Recombinant

Insulin, Human Recombinant

Synonyms Insulin sodium salt human; rh-Insulin

CAS Number: 11061-68-0 Molecular Formula: C257H383N65O77S6 Molecular Weight: 5807.629 g/mol

MDL Number: MFCD00131380

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SKU 02193900-CF
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Description

Product Description

Insulin, Human Recombinant

Application Notes

Methods for immobilizing insulin on polystyrene dishes have been reported for applications involving protein-free cell cultures.

Usage Statement

Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Specifications
SKU 02193900-CF
Alternate Names Insulin sodium salt human; rh-Insulin
Analysis Note Two-chain polypeptide hormone produced by the β-cells of pancreatic islets. Its molecular weight is ~5800 Da. The α and β chains are joined by two interchain disulfide bonds. The α chain contains an intrachain disulfide bond. Insulin regulates the cellular uptake, utilization, and storage of glucose, amino acids, and fatty acids and inhibits the breakdown of glycogen, protein, and fat
Application Notes Methods for immobilizing insulin on polystyrene dishes have been reported for applications involving protein-free cell cultures.
Biochemical Physiological Actions Two-chain polypeptide hormone produced by the ß-cells of pancreatic islets. Its molecular weight is ~5800 Da. The a and ß chains are joined by two interchain disulfide bonds. The a chain contains an intrachain disulfide bond. Insulin regulates the cellular uptake, utilization, and storage of glucose, amino acids, and fatty acids and inhibits the breakdown of glycogen, protein, and fat.
Extinction Coefficient EM (278 nm): 6080 (33 mM phosphate, pH 7.0, bovine and porcine) (Lit.)
Format powder
Hazard Statements H317
Isoelectric Point ~5.3 (for the native protein)(Lit.)
MDL # MFCD00131380
Melting Point 81 °C
Molecular Formula C257H383N65O77S6
Molecular Weight 5807.629 g/mol
Physical Appearance Powder
Product Families Description Insulin
Product Overview Insulin, Human Recombinant
RTECS Number NM8900250
Specific Activity ~28 IU/mg
Storage and Handling Store at -20 °C.
Typical Working Concentration 1 to 10 ug/mL for cell culture
Unit Definition 1 unit corresponds to the efficiency of 0.04167 mg international standard substance. An HPLC method exists to test the potency.
Usage Statement Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.