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Paclitaxel

Paclitaxel

Synonyms Taxol® (Bristol-Myers Squibb); Taxol A; NSC 125973

CAS Number: 33069-62-4 Molecular Formula: C47H51NO14 Molecular Weight: 853.918 g/mol

Beilstein Registry Number: 1420457 MDL Number: MFCD00869953

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SKU 02193532-CF
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Description

Product Description

Paclitaxel

Application Notes

Paclitaxel has been used as a component of the dechorionation buffer for Gryllus bimaculatus eggs. Paclitaxel has also been used for studying its effect on the movement of all-trans retinoic acid (ATRA) differentiated NB4 cells.

Usage Statement

Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Key Applications

Anti-neoplastic agent||Anti-mitotic drug||Antitumor agent||Antileukemic agent

Specifications
SKU 02193532-CF
Application Notes Paclitaxel has been used as a component of the dechorionation buffer for Gryllus bimaculatus eggs. Paclitaxel has also been used for studying its effect on the movement of all-trans retinoic acid (ATRA) differentiated NB4 cells.
Beilstein Registry Number 1420457
Biochemical Physiological Actions Antitumor and antileukemic agent which lowers the critical concentration for tubulin polymerization and reversibly binds to tubulin prohibiting depolymerization; binds to the N-terminal region of beta-tubulin and promotes the formation of highly stable microtubles that resist depolymerization, thus preventing normal cell division and arresting the cell cycle at the G2-M phase. The microtubule damage induces apoptosis through a JNK-dependent pathway in the early phase followed by a JNK-independent pathway, perhaps related to the activation of protein kinase A or of Raf-1 kinase, that results in phosphorylation of Bcl-2.
Format powder
Hazard Statements H315-H317-H318-H334-H335-H341-H361-H371
Applications Anti-neoplastic agent||Anti-mitotic drug||Antitumor agent||Antileukemic agent
Melting Point 415 to 421° F (NTP, 1992)
Molecular Formula C47H51NO14
Molecular Weight 853.918 g/mol
Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator, Gloves, respirator cartridge, respirator filter
Physical Appearance White Powder
Product Families Description Paclitaxel
Product Overview Paclitaxel
Purity ≥98%
RTECS Number DA8340700
Safety Symbol GHS05, GHS07, GHS08
Solubility <h5 class="minor-section-title">Water Solubility</h5>Insoluble
Source Taxus brevifolia(Pacific Yew Bark)
Storage and Handling -20°C
Usage Statement Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.