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Furazolidone

Furazolidone

Synonyms 3-[[(5-Nitro-2-furanyl)methylene]-amino]-2-oxazolidinone; 3-(5-nitrofurfurylideneamino)-2-oxazolidinone; N-(5-nitro-2-furfurylidene)-3-amino-2-oxazolidone; Furovag; Furoxane; Medaron; Topazone

CAS Number: 67-45-8 Molecular Formula: C8H7N3O5 Molecular Weight: 225.16 g/mol

Beilstein Registry Number: 8317414 EC Number: 200-653-3 MDL Number: MFCD00010550

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SKU 02193465-CF
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Description

Product Description

Furazolidone

Application Notes

Furazolidone is a nitrofuran derivative with antiprotozoal and antibacterial activity. Furazolidone binds bacterial DNA, which leads to the gradual inhibition of monoamine oxidase. It is used to treat anorexia and antagonism of thiamin utilization in poultry. Furazolidone increases thapsigargin-sensitive Ca2+-ATPase in chick cardiac myocytes. It also used as a DNA interstrand cross-linking agent.

Usage Statement

Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Key Applications

Antibacterial

Specifications
SKU 02193465-CF
Application Notes Furazolidone is a nitrofuran derivative with antiprotozoal and antibacterial activity. Furazolidone binds bacterial DNA, which leads to the gradual inhibition of monoamine oxidase. It is used to treat anorexia and antagonism of thiamin utilization in poultry. Furazolidone increases thapsigargin-sensitive Ca2+-ATPase in chick cardiac myocytes. It also used as a DNA interstrand cross-linking agent.
Beilstein Registry Number 8317414
Biochemical Physiological Actions Furazolidone and its generated free radicals, may bind to DNA and induce cross-links. Bacterial DNA is particularly susceptible to this drug, which results in high levels of mutations (transitions and transversions) in the bacterial chromosome. Its mechanism of action minimizes the development of resistant organisms. Furazolidone is a monoamine oxidase (MAO) inhibitor. It increases thapsigargin-sensitive Ca2+-ATPase in chick cardiac myocytes.
EC Number 200-653-3
Format powder
Hazard Statements H361
Applications Antibacterial
Melting Point 254-256
Molecular Formula C8H7N3O5
Molecular Weight 225.16 g/mol
Personal Protective Equipment Eyeshields, full-face particle respirator, Gloves, respirator filter,respirator cartridges
Physical Appearance Yellow Powder
Product Families Description Furazolidone
Product Overview Furazolidone
RTECS Number RQ3675000
Safety Symbol GHS08
Solubility Water Solubility40 mg/L (at 25 °C)
Storage and Handling Store at Room Temperature (15-30 °C). Protect from light.
Usage Statement Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.