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Folinic Acid Calcium Salt, Pentahydrate

Folinic Acid Calcium Salt, Pentahydrate

Synonyms 5-Formyl-5,6,7,8-tetrahydrofolic acid calcium salt; 5-Formyl-5,6,7,8-tetrahydropteroyl-L-glutamic acid calcium salt; 5-HCO-H4PteGlu; Calcium folinate; Citrovorum factor calcium salt; Leucovorin calcium salt; N5-Formyl-5,6,7,8- tetrahydropteroyl-L-glutamic acid calcium salt; CF; N-[p-[[(2-amino-5-formyl-5,6,7,8-tetrahydro-4- hydroxy-6- pteridinyl) methyl] amino] benzoyl] glutamic acid calcium salt; N-[4-[[(2-Amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl) methyl] amino] benzoyl]-Lglutamic acid calcium salt

CAS Number: 1492-18-8 Molecular Formula: C20H21N7O7Ca Molecular Weight: 511.508 g/mol

Beilstein Registry Number: 5723924 EC Number: 216-082-8

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SKU 02191504-CF
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Description

Product Description

Folinic Acid Calcium Salt, Pentahydrate

Application Notes

Folinic Acid Calcium Salt, Pentahydrate offsets the effects of folic acid antagonists that act by binding dihydrofolate reductase and blocking the conversion of folic acid to tetrahydrofolate. In medicine, calcium folinate is used after treatment with methotrexate to reduce the toxicity of the methotrexate. Calcium folinate is also used to enhance the cytotoxic effect of 5-fluorouracil in the treatment of cancer.

Usage Statement

Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.

Specifications
SKU 02191504-CF
Application Notes Folinic Acid Calcium Salt, Pentahydrate offsets the effects of folic acid antagonists that act by binding dihydrofolate reductase and blocking the conversion of folic acid to tetrahydrofolate. In medicine, calcium folinate is used after treatment with methotrexate to reduce the toxicity of the methotrexate. Calcium folinate is also used to enhance the cytotoxic effect of 5-fluorouracil in the treatment of cancer.
Beilstein Registry Number 5723924
Biochemical Physiological Actions Intermediate product of the metabolism of folic acid; the active form into which that acid is converted in the body, ascorbic acid being a necessary factor in the conversion process.
EC Number 216-082-8
Format powder
Hazard Statements H315-H317-H319-H334-H335
Molecular Formula C20H21N7O7Ca
Molecular Weight 511.508 g/mol
Physical Appearance Light Yellow Powder
Product Families Description Folinic acid calcium salt
Product Overview Folinic Acid Calcium Salt, Pentahydrate
RTECS Number MA0600500
Safety Symbol GHS07, GHS08
Solubility DMSO « 1 (mg/mL)
Storage and Handling Store at Room Temperature (15-30 °C). Protect from light.
Usage Statement Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.