Staurosporine

Staurosporine

Synonyms Staurosporin; Antibiotic AM-2282

CAS Number: 62996-74-1 Molecular Formula: C28H26N4O3 Molecular Weight: 466.541 g/mol

Beilstein Registry Number: 1060573 MDL Number: MFCD00077402

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SKU 02191400-CF
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Description

Product Description

Staurosporine

Application Notes

Starosporin is use to study the involvement of protein kinases in signal transduction pathways. It arrests normal cells in the G1 checkpoint.Starosporin is used as a potent inhibitor of Protein kinase C and other protein kinases in vitro and in cultured cells, an inducer of apoptosis in many mammalian cell types.

Usage Statement

Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Key Applications

Staurosporine can cross cell membranes in 0.5 to 2.0 hours and has been shown to function in both plant and mammalian systems

Specifications
SKU 02191400-CF
Alternate Names Staurosporin; Antibiotic AM-2282
Application Notes Starosporin is use to study the involvement of protein kinases in signal transduction pathways. It arrests normal cells in the G1 checkpoint.Starosporin is used as a potent inhibitor of Protein kinase C and other protein kinases in vitro and in cultured cells, an inducer of apoptosis in many mammalian cell types.
Beilstein Registry Number 1060573
Biochemical Physiological Actions Potent inhibitor of phospholipid/calcium-dependent protein kinase. Inhibits the upregulation of VEGF expression in tumor cells. Partially reverses MDR, sensitizing cells with MDR phenotype to cytotoxic agents. Inhibits Pgp phosphorylation. However, functional significance of Pgp phosphorylation is ill defined.
Hazard Statements H304-H340-H350
Applications Staurosporine can cross cell membranes in 0.5 to 2.0 hours and has been shown to function in both plant and mammalian systems
MDL # MFCD00077402
Molecular Formula C28H26N4O3
Molecular Weight 466.541 g/mol
Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type, Gloves, respirator
Physical Appearance White to off white powder
Product Families Description Staurosporine
Product Overview Staurosporine
Purity ≥98%
Safety Symbol GHS08
Source Streptomyces species
Storage and Handling Store at 2-8 °C & Protect from light.
Usage Statement Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.